Single-Cell Profiling of Ebola Virus Disease In Vivo Reveals Viral and Host Dynamics

Kotliar, Dylan; Lin, Aaron E; Logue, James; Hughes, Travis K; Khoury, Nadine M; Raju, Siddharth S; Wadsworth, Marc H; Chen, Han; Kurtz, Jonathan R; Dighero-Kemp, Bonnie; Bjornson, Zach B; Mukherjee, Nilanjan; Sellers, Brian A; Tran, Nancy; Bauer, Matthew R; Adams, Gordon C; Adams, Ricky; Rinn, John L; Melé, Marta; Schaffner, Stephen F; Nolan, Garry P; Barnes, Kayla G; Hensley, Lisa E; McIlwain, David R; Shalek, Alex K; Sabeti, Pardis C; Bennett, Richard S

Author(s)

Kotliar, Dylan; Lin, Aaron E; Logue, James; Hughes, Travis K; Khoury, Nadine M; ... Show more

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Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/

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Abstract

© 2020 The Author(s) Single-cell profiling of circulating immune cells during Ebola virus (EBOV) infection in non-human primates resolves molecular correlates of viral tropism, characterizes replication dynamics within infected cells, and distinguishes expression changes that are mediated by viral infection from those due to cytokine signaling.

Date issued

2020

URI

https://hdl.handle.net/1721.1/141290

Department

Harvard University--MIT Division of Health Sciences and Technology; Massachusetts Institute of Technology. Department of Chemistry; Massachusetts Institute of Technology. Institute for Medical Engineering & Science; Koch Institute for Integrative Cancer Research at MIT; Ragon Institute of MGH, MIT and Harvard

Journal

Cell

Publisher

Elsevier BV

Citation

Kotliar, Dylan, Lin, Aaron E, Logue, James, Hughes, Travis K, Khoury, Nadine M et al. 2020. "Single-Cell Profiling of Ebola Virus Disease In Vivo Reveals Viral and Host Dynamics." Cell, 183 (5).

Version: Final published version

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