A Robust Method for Perfusable Microvascular Network Formation In Vitro

Author(s)
Wan, Zhengpeng; Zhong, Amy X; Zhang, Shun; Pavlou, Georgios; Coughlin, Mark F; ... Show more
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Abstract
Micropost-based microfluidic devices are widely used for microvascular network (MVN) formation in diverse research fields. However, consistently generating perfusable MVNs of physiological morphology and dimension has proven to be challenging. Here, how initial seeding parameters determine key characteristics of MVN formation is investigated and a robust two-step seeding strategy to generate perfusable physiological MVNs in microfluidic devices is established.
Date issued
2022-04-03
URI
https://hdl.handle.net/1721.1/142858
Department
Massachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Mechanical Engineering
Journal
Small Methods
Publisher
Wiley
Citation
Wan, Zhengpeng, Zhong, Amy X, Zhang, Shun, Pavlou, Georgios, Coughlin, Mark F et al. 2022. "A Robust Method for Perfusable Microvascular Network Formation In Vitro." Small Methods.
Version: Final published version
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