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dc.contributor.authorDani, Neil
dc.contributor.authorHerbst, Rebecca H
dc.contributor.authorMcCabe, Cristin
dc.contributor.authorGreen, Gilad S
dc.contributor.authorKaiser, Karol
dc.contributor.authorHead, Joshua P
dc.contributor.authorCui, Jin
dc.contributor.authorShipley, Frederick B
dc.contributor.authorJang, Ahram
dc.contributor.authorDionne, Danielle
dc.contributor.authorNguyen, Lan
dc.contributor.authorRodman, Christopher
dc.contributor.authorRiesenfeld, Samantha J
dc.contributor.authorProchazka, Jan
dc.contributor.authorProchazkova, Michaela
dc.contributor.authorSedlacek, Radislav
dc.contributor.authorZhang, Feng
dc.contributor.authorBryja, Vitezslav
dc.contributor.authorRozenblatt-Rosen, Orit
dc.contributor.authorHabib, Naomi
dc.contributor.authorRegev, Aviv
dc.contributor.authorLehtinen, Maria K
dc.date.accessioned2022-06-15T16:55:31Z
dc.date.available2022-06-15T16:55:31Z
dc.date.issued2021
dc.identifier.urihttps://hdl.handle.net/1721.1/143444
dc.description.abstractThe choroid plexus (ChP) in each brain ventricle produces cerebrospinal fluid (CSF) and forms the blood-CSF barrier. Here, we construct a single-cell and spatial atlas of each ChP in the developing, adult, and aged mouse brain. We delineate diverse cell types, subtypes, cell states, and expression programs in epithelial and mesenchymal cells across ages and ventricles. In the developing ChP, we predict a common progenitor pool for epithelial and neuronal cells, validated by lineage tracing. Epithelial and fibroblast cells show regionalized expression by ventricle, starting at embryonic stages and persisting with age, with a dramatic transcriptional shift with maturation, and a smaller shift in each aged cell type. With aging, epithelial cells upregulate host-defense programs, and resident macrophages upregulate interleukin-1β (IL-1β) signaling genes. Our atlas reveals cellular diversity, architecture and signaling across ventricles during development, maturation, and aging of the ChP-brain barrier.en_US
dc.language.isoen
dc.publisherElsevier BVen_US
dc.relation.isversionof10.1016/J.CELL.2021.04.003en_US
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs Licenseen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.sourcePMCen_US
dc.titleA cellular and spatial map of the choroid plexus across brain ventricles and agesen_US
dc.typeArticleen_US
dc.identifier.citationDani, Neil, Herbst, Rebecca H, McCabe, Cristin, Green, Gilad S, Kaiser, Karol et al. 2021. "A cellular and spatial map of the choroid plexus across brain ventricles and ages." Cell, 184 (11).
dc.contributor.departmentMcGovern Institute for Brain Research at MIT
dc.contributor.departmentMassachusetts Institute of Technology. Department of Brain and Cognitive Sciences
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineering
dc.contributor.departmentKoch Institute for Integrative Cancer Research at MIT
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biology
dc.relation.journalCellen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2022-06-15T16:51:58Z
dspace.orderedauthorsDani, N; Herbst, RH; McCabe, C; Green, GS; Kaiser, K; Head, JP; Cui, J; Shipley, FB; Jang, A; Dionne, D; Nguyen, L; Rodman, C; Riesenfeld, SJ; Prochazka, J; Prochazkova, M; Sedlacek, R; Zhang, F; Bryja, V; Rozenblatt-Rosen, O; Habib, N; Regev, A; Lehtinen, MKen_US
dspace.date.submission2022-06-15T16:52:03Z
mit.journal.volume184en_US
mit.journal.issue11en_US
mit.licensePUBLISHER_CC
mit.metadata.statusAuthority Work and Publication Information Neededen_US


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