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dc.contributor.authorGunaratne, Chathika
dc.contributor.authorReyes, Rene
dc.contributor.authorHemberg, Erik
dc.contributor.authorO’Reilly, Una-May
dc.date.accessioned2022-06-15T18:15:50Z
dc.date.available2022-06-15T18:15:50Z
dc.date.issued2022-04-13
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/1721.1/143455
dc.description.abstract<jats:title>Abstract</jats:title><jats:p>Contagious respiratory diseases, such as COVID-19, depend on sufficiently prolonged exposures for the successful transmission of the underlying pathogen. It is important that organizations evaluate the efficacy of non-pharmaceutical interventions aimed at mitigating viral transmission among their personnel. We have developed a operational risk assessment simulation framework that couples a spatial agent-based model of movement with an agent-based SIR model to assess the relative risks of different intervention strategies. By applying our model on MIT’s Stata center, we assess the impacts of three possible dimensions of intervention: one-way vs unrestricted movement, population size allowed onsite, and frequency of leaving designated work location for breaks. We find that there is no significant impact made by one-way movement restrictions over unrestricted movement. Instead, we find that reducing the frequency at which individuals leave their workstations combined with lowering the number of individuals admitted below the current recommendations lowers the likelihood of highly connected individuals within the contact networks that emerge, which in turn lowers the overall risk of infection. We discover three classes of possible interventions based on their epidemiological effects. By assuming a direct relationship between data on secondary attack rates and transmissibility in the agent-based SIR model, we compare relative infection risk of four respiratory illnesses, MERS, SARS, COVID-19, and Measles, within the simulated area, and recommend appropriate intervention guidelines.</jats:p>en_US
dc.publisherSpringer Science and Business Media LLCen_US
dc.relation.isversionof10.1038/s41598-022-09942-yen_US
dc.rightsCreative Commons Attribution 4.0 International licenseen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.sourceScientific Reportsen_US
dc.titleEvaluating efficacy of indoor non-pharmaceutical interventions against COVID-19 outbreaks with a coupled spatial-SIR agent-based simulation frameworken_US
dc.typeArticleen_US
dc.identifier.citationGunaratne, Chathika, Reyes, Rene, Hemberg, Erik and O’Reilly, Una-May. 2022. "Evaluating efficacy of indoor non-pharmaceutical interventions against COVID-19 outbreaks with a coupled spatial-SIR agent-based simulation framework." 12 (1).
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.date.submission2022-06-15T17:55:53Z
mit.journal.volume12en_US
mit.journal.issue1en_US
mit.licensePUBLISHER_CC
mit.metadata.statusAuthority Work and Publication Information Neededen_US


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