Engineering the Modular Receptor-Binding Proteins of Klebsiella Phages Switches Their Capsule Serotype Specificity

Author(s)
Latka, Agnieszka; Lemire, Sebastien; Grimon, Dennis; Dams, Dorien; Maciejewska, Barbara; ... Show more
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Abstract
<jats:p>The antimicrobial resistance crisis has rekindled interest in bacteriophage therapy. Phages have been studied over a century as therapeutics to treat bacterial infections, but one of the biggest challenges for the use of phages in therapeutic interventions remains their high specificity.</jats:p>
Date issued
2021
URI
https://hdl.handle.net/1721.1/143757
Department
Massachusetts Institute of Technology. Synthetic Biology Center; Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science; Massachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Research Laboratory of Electronics; Singapore-MIT Alliance in Research and Technology (SMART)
Journal
mBio
Publisher
American Society for Microbiology
Citation
Latka, Agnieszka, Lemire, Sebastien, Grimon, Dennis, Dams, Dorien, Maciejewska, Barbara et al. 2021. "Engineering the Modular Receptor-Binding Proteins of Klebsiella Phages Switches Their Capsule Serotype Specificity." mBio, 12 (3).
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