Permitted and restricted steps of human kinetochore assembly in mitotic cell extracts
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<jats:p> This work represents the first systematic analysis of kinetochore assembly in human mitotic cell extracts. Using recombinant and native proteins, we show that only a few assembly steps are permitted, suggesting that multiple mechanisms guard against the spurious formation of microtubule-binding kinetochore particles in the cytoplasm of mitotic cells. </jats:p>
Date issued
2021Department
Massachusetts Institute of Technology. Department of BiologyJournal
Molecular Biology of the Cell
Publisher
American Society for Cell Biology (ASCB)
Citation
Tarasovetc, Ekaterina V, Allu, Praveen Kumar, Wimbish, Robert T, DeLuca, Jennifer G, Cheeseman, Iain M et al. 2021. "Permitted and restricted steps of human kinetochore assembly in mitotic cell extracts." Molecular Biology of the Cell, 32 (13).
Version: Final published version