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dc.contributor.authorTakeuchi, Daigo
dc.contributor.authorRoy, Dheeraj
dc.contributor.authorMuralidhar, Shruti
dc.contributor.authorKawai, Takashi
dc.contributor.authorBari, Andrea
dc.contributor.authorLovett, Chanel
dc.contributor.authorSullivan, Heather A
dc.contributor.authorWickersham, Ian R
dc.contributor.authorTonegawa, Susumu
dc.date.accessioned2023-01-06T13:47:37Z
dc.date.available2023-01-06T13:47:37Z
dc.date.issued2022
dc.identifier.urihttps://hdl.handle.net/1721.1/146990
dc.description.abstract<jats:title>Abstract</jats:title><jats:p>Anterior cingulate cortex mediates the flexible updating of an animal’s choice responses upon rule changes in the environment. However, how anterior cingulate cortex entrains motor cortex to reorganize rule representations and generate required motor outputs remains unclear. Here, we demonstrate that chemogenetic silencing of the terminal projections of cingulate cortical neurons in secondary motor cortex in the rat disrupts choice performance in trials immediately following rule switches, suggesting that these inputs are necessary to update rule representations for choice decisions stored in the motor cortex. Indeed, the silencing of cingulate cortex decreases rule selectivity of secondary motor cortical neurons. Furthermore, optogenetic silencing of cingulate cortical neurons that is temporally targeted to error trials immediately after rule switches exacerbates errors in the following trials. These results suggest that cingulate cortex monitors behavioral errors and updates rule representations in motor cortex, revealing a critical role for cingulate-motor circuits in adaptive choice behaviors.</jats:p>en_US
dc.language.isoen
dc.publisherSpringer Science and Business Media LLCen_US
dc.relation.isversionof10.1038/S41467-022-32142-1en_US
dc.rightsCreative Commons Attribution 4.0 International licenseen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.sourceNatureen_US
dc.titleCingulate-motor circuits update rule representations for sequential choice decisionsen_US
dc.typeArticleen_US
dc.identifier.citationTakeuchi, Daigo, Roy, Dheeraj, Muralidhar, Shruti, Kawai, Takashi, Bari, Andrea et al. 2022. "Cingulate-motor circuits update rule representations for sequential choice decisions." Nature Communications, 13 (1).
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.relation.journalNature Communicationsen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2023-01-06T13:42:12Z
dspace.orderedauthorsTakeuchi, D; Roy, D; Muralidhar, S; Kawai, T; Bari, A; Lovett, C; Sullivan, HA; Wickersham, IR; Tonegawa, Sen_US
dspace.date.submission2023-01-06T13:42:15Z
mit.journal.volume13en_US
mit.journal.issue1en_US
mit.licensePUBLISHER_CC
mit.metadata.statusAuthority Work and Publication Information Neededen_US


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