Design and synthesis of a new orthogonally protected glutamic acid analog and its use in the preparation of high affinity polo-like kinase 1 polo-box domain – binding peptide macrocycles

Author(s)
Hymel, David; Tsuji, Kohei; Grant, Robert A; Chingle, Ramesh M; Kunciw, Dominique L; ... Show more
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Creative Commons Attribution NonCommercial License 4.0 https://creativecommons.org/licenses/by-nc/4.0/
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Abstract
<jats:p>A novel macrocyclic peptide strategy utilizing a glutamic acid analog that can work as an alkylated histidine replacement.</jats:p>
Date issued
2021
URI
https://hdl.handle.net/1721.1/147021
Department
Massachusetts Institute of Technology. Department of Biology
Journal
Organic and Biomolecular Chemistry
Publisher
Royal Society of Chemistry (RSC)
Citation
Hymel, David, Tsuji, Kohei, Grant, Robert A, Chingle, Ramesh M, Kunciw, Dominique L et al. 2021. "Design and synthesis of a new orthogonally protected glutamic acid analog and its use in the preparation of high affinity polo-like kinase 1 polo-box domain – binding peptide macrocycles." Organic and Biomolecular Chemistry, 19 (36).
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