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dc.contributor.authorVickovic, Sanja
dc.contributor.authorSchapiro, Denis
dc.contributor.authorCarlberg, Konstantin
dc.contributor.authorLötstedt, Britta
dc.contributor.authorLarsson, Ludvig
dc.contributor.authorHildebrandt, Franziska
dc.contributor.authorKorotkova, Marina
dc.contributor.authorHensvold, Aase H
dc.contributor.authorCatrina, Anca I
dc.contributor.authorSorger, Peter K
dc.contributor.authorMalmström, Vivianne
dc.contributor.authorRegev, Aviv
dc.contributor.authorStåhl, Patrik L
dc.date.accessioned2023-01-13T16:55:38Z
dc.date.available2023-01-13T16:55:38Z
dc.date.issued2022
dc.identifier.urihttps://hdl.handle.net/1721.1/147101
dc.description.abstract<jats:title>Abstract</jats:title><jats:p>The inflamed rheumatic joint is a highly heterogeneous and complex tissue with dynamic recruitment and expansion of multiple cell types that interact in multifaceted ways within a localized area. Rheumatoid arthritis synovium has primarily been studied either by immunostaining or by molecular profiling after tissue homogenization. Here, we use Spatial Transcriptomics, where tissue-resident RNA is spatially labeled in situ with barcodes in a transcriptome-wide fashion, to study local tissue interactions at the site of chronic synovial inflammation. We report comprehensive spatial RNA-Seq data coupled to cell type-specific localization patterns at and around organized structures of infiltrating leukocyte cells in the synovium. Combining morphological features and high-throughput spatially resolved transcriptomics may be able to provide higher statistical power and more insights into monitoring disease severity and treatment-specific responses in seropositive and seronegative rheumatoid arthritis.</jats:p>en_US
dc.language.isoen
dc.publisherSpringer Science and Business Media LLCen_US
dc.relation.isversionof10.1038/S42003-022-03050-3en_US
dc.rightsCreative Commons Attribution 4.0 International licenseen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.sourceNatureen_US
dc.titleThree-dimensional spatial transcriptomics uncovers cell type localizations in the human rheumatoid arthritis synoviumen_US
dc.typeArticleen_US
dc.identifier.citationVickovic, Sanja, Schapiro, Denis, Carlberg, Konstantin, Lötstedt, Britta, Larsson, Ludvig et al. 2022. "Three-dimensional spatial transcriptomics uncovers cell type localizations in the human rheumatoid arthritis synovium." Communications Biology, 5 (1).
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.relation.journalCommunications Biologyen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2023-01-13T15:35:14Z
dspace.orderedauthorsVickovic, S; Schapiro, D; Carlberg, K; Lötstedt, B; Larsson, L; Hildebrandt, F; Korotkova, M; Hensvold, AH; Catrina, AI; Sorger, PK; Malmström, V; Regev, A; Ståhl, PLen_US
dspace.date.submission2023-01-13T15:35:19Z
mit.journal.volume5en_US
mit.journal.issue1en_US
mit.licensePUBLISHER_CC
mit.metadata.statusAuthority Work and Publication Information Neededen_US


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