dc.contributor.author | Vickovic, Sanja | |
dc.contributor.author | Schapiro, Denis | |
dc.contributor.author | Carlberg, Konstantin | |
dc.contributor.author | Lötstedt, Britta | |
dc.contributor.author | Larsson, Ludvig | |
dc.contributor.author | Hildebrandt, Franziska | |
dc.contributor.author | Korotkova, Marina | |
dc.contributor.author | Hensvold, Aase H | |
dc.contributor.author | Catrina, Anca I | |
dc.contributor.author | Sorger, Peter K | |
dc.contributor.author | Malmström, Vivianne | |
dc.contributor.author | Regev, Aviv | |
dc.contributor.author | Ståhl, Patrik L | |
dc.date.accessioned | 2023-01-13T16:55:38Z | |
dc.date.available | 2023-01-13T16:55:38Z | |
dc.date.issued | 2022 | |
dc.identifier.uri | https://hdl.handle.net/1721.1/147101 | |
dc.description.abstract | <jats:title>Abstract</jats:title><jats:p>The inflamed rheumatic joint is a highly heterogeneous and complex tissue with dynamic recruitment and expansion of multiple cell types that interact in multifaceted ways within a localized area. Rheumatoid arthritis synovium has primarily been studied either by immunostaining or by molecular profiling after tissue homogenization. Here, we use Spatial Transcriptomics, where tissue-resident RNA is spatially labeled in situ with barcodes in a transcriptome-wide fashion, to study local tissue interactions at the site of chronic synovial inflammation. We report comprehensive spatial RNA-Seq data coupled to cell type-specific localization patterns at and around organized structures of infiltrating leukocyte cells in the synovium. Combining morphological features and high-throughput spatially resolved transcriptomics may be able to provide higher statistical power and more insights into monitoring disease severity and treatment-specific responses in seropositive and seronegative rheumatoid arthritis.</jats:p> | en_US |
dc.language.iso | en | |
dc.publisher | Springer Science and Business Media LLC | en_US |
dc.relation.isversionof | 10.1038/S42003-022-03050-3 | en_US |
dc.rights | Creative Commons Attribution 4.0 International license | en_US |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_US |
dc.source | Nature | en_US |
dc.title | Three-dimensional spatial transcriptomics uncovers cell type localizations in the human rheumatoid arthritis synovium | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Vickovic, Sanja, Schapiro, Denis, Carlberg, Konstantin, Lötstedt, Britta, Larsson, Ludvig et al. 2022. "Three-dimensional spatial transcriptomics uncovers cell type localizations in the human rheumatoid arthritis synovium." Communications Biology, 5 (1). | |
dc.contributor.department | Massachusetts Institute of Technology. Department of Biology | en_US |
dc.relation.journal | Communications Biology | en_US |
dc.eprint.version | Final published version | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dc.date.updated | 2023-01-13T15:35:14Z | |
dspace.orderedauthors | Vickovic, S; Schapiro, D; Carlberg, K; Lötstedt, B; Larsson, L; Hildebrandt, F; Korotkova, M; Hensvold, AH; Catrina, AI; Sorger, PK; Malmström, V; Regev, A; Ståhl, PL | en_US |
dspace.date.submission | 2023-01-13T15:35:19Z | |
mit.journal.volume | 5 | en_US |
mit.journal.issue | 1 | en_US |
mit.license | PUBLISHER_CC | |
mit.metadata.status | Authority Work and Publication Information Needed | en_US |