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dc.contributor.authorConwill, Arolyn
dc.contributor.authorKuan, Anne C
dc.contributor.authorDamerla, Ravalika
dc.contributor.authorPoret, Alexandra J
dc.contributor.authorBaker, Jacob S
dc.contributor.authorTripp, A Delphine
dc.contributor.authorAlm, Eric J
dc.contributor.authorLieberman, Tami D
dc.date.accessioned2023-01-26T14:20:36Z
dc.date.available2023-01-26T14:20:36Z
dc.date.issued2022
dc.identifier.urihttps://hdl.handle.net/1721.1/147721
dc.description.abstractWhat enables strains of the same species to coexist in a microbiome? Here, we investigate whether host anatomy can explain strain co-residence of Cutibacterium acnes, the most abundant species on human skin. We reconstruct on-person evolution and migration using whole-genome sequencing of C. acnes colonies acquired from healthy subjects, including from individual skin pores, and find considerable spatial structure at the level of pores. Although lineages (sets of colonies separated by <100 mutations) with in vitro fitness differences coexist within centimeter-scale regions, each pore is dominated by a single lineage. Moreover, colonies from a pore typically have identical genomes. An absence of adaptive signatures suggests a genotype-independent source of low within-pore diversity. We therefore propose that pore anatomy imposes random single-cell bottlenecks; the resulting population fragmentation reduces competition and promotes coexistence. Our findings suggest that therapeutic interventions involving pore-dwelling species might focus on removing resident populations over optimizing probiotic fitness.en_US
dc.language.isoen
dc.publisherElsevier BVen_US
dc.relation.isversionof10.1016/J.CHOM.2021.12.007en_US
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs Licenseen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.sourceElsevieren_US
dc.titleAnatomy promotes neutral coexistence of strains in the human skin microbiomeen_US
dc.typeArticleen_US
dc.identifier.citationConwill, Arolyn, Kuan, Anne C, Damerla, Ravalika, Poret, Alexandra J, Baker, Jacob S et al. 2022. "Anatomy promotes neutral coexistence of strains in the human skin microbiome." Cell Host and Microbe, 30 (2).
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.relation.journalCell Host and Microbeen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2023-01-26T14:17:33Z
dspace.orderedauthorsConwill, A; Kuan, AC; Damerla, R; Poret, AJ; Baker, JS; Tripp, AD; Alm, EJ; Lieberman, TDen_US
dspace.date.submission2023-01-26T14:17:36Z
mit.journal.volume30en_US
mit.journal.issue2en_US
mit.licensePUBLISHER_CC
mit.metadata.statusAuthority Work and Publication Information Neededen_US


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