CRISPR Interference Reveals That All- Trans -Retinoic Acid Promotes Macrophage Control of Mycobacterium tuberculosis by Limiting Bacterial Access to Cholesterol and Propionyl Coenzyme A

Author(s)
Babunovic, Gregory H; DeJesus, Michael A; Bosch, Barbara; Chase, Michael R; Barbier, Thibault; ... Show more
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Abstract
<jats:p> Tuberculosis, caused by the bacterium <jats:named-content content-type="genus-species">Mycobacterium tuberculosis</jats:named-content> , is a leading cause of death due to infectious disease. Improving the immune response to tuberculosis holds promise for fighting the disease but is limited by our lack of knowledge as to how the immune system kills <jats:named-content content-type="genus-species">M. tuberculosis</jats:named-content> . </jats:p>
Date issued
2022
URI
https://hdl.handle.net/1721.1/147781
Department
Massachusetts Institute of Technology. Department of Biological Engineering
Journal
mBio
Publisher
American Society for Microbiology
Citation
Babunovic, Gregory H, DeJesus, Michael A, Bosch, Barbara, Chase, Michael R, Barbier, Thibault et al. 2022. "CRISPR Interference Reveals That All- Trans -Retinoic Acid Promotes Macrophage Control of Mycobacterium tuberculosis by Limiting Bacterial Access to Cholesterol and Propionyl Coenzyme A." mBio, 13 (1).
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