Reeling it in: how DNA topology drives loop extrusion by condensin

Author(s)
Narducci, Domenic N; Hansen, Anders S
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Abstract
Structural maintenance of chromosomes (SMC) complexes such as condensin regulate chromosome organization by extruding loops. A new study uses single-molecule imaging of condensin on supercoiled DNA to understand how condensins navigate the under- and overwound DNA states common throughout the genome.
Date issued
2022
URI
https://hdl.handle.net/1721.1/147832
Department
Massachusetts Institute of Technology. Department of Biological Engineering
Journal
Nature Structural and Molecular Biology
Publisher
Springer Science and Business Media LLC
Citation
Narducci, Domenic N and Hansen, Anders S. 2022. "Reeling it in: how DNA topology drives loop extrusion by condensin." Nature Structural and Molecular Biology, 29 (7).
Version: Author's final manuscript
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