Sequential immunization of macaques elicits heterologous neutralizing antibodies targeting the V3-glycan patch of HIV-1 Env

Escolano, Amelia; Gristick, Harry B; Gautam, Rajeev; DeLaitsch, Andrew T; Abernathy, Morgan E; Yang, Zhi; Wang, Haoqing; Hoffmann, Magnus AG; Nishimura, Yoshiaki; Wang, Zijun; Koranda, Nicholas; Kakutani, Leesa M; Gao, Han; Gnanapragasam, Priyanthi NP; Raina, Henna; Gazumyan, Ana; Cipolla, Melissa; Oliveira, Thiago Y; Ramos, Victor; Irvine, Darrell J; Silva, Murillo; West, Anthony P; Keeffe, Jennifer R; Barnes, Christopher O; Seaman, Michael S; Nussenzweig, Michel C; Martin, Malcolm A; Bjorkman, Pamela J

Author(s)

Escolano, Amelia; Gristick, Harry B; Gautam, Rajeev; DeLaitsch, Andrew T; Abernathy, Morgan E; ... Show more

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Abstract

Sequential immunization elicits antibodies against the V3-glycan patch of HIV-1 Env in rhesus macaques and also induces off-target antibody responses.

Date issued

2021

URI

https://hdl.handle.net/1721.1/147838

Department

Massachusetts Institute of Technology. Department of Biological Engineering

Journal

Science Translational Medicine

Publisher

American Association for the Advancement of Science (AAAS)

Citation

Escolano, Amelia, Gristick, Harry B, Gautam, Rajeev, DeLaitsch, Andrew T, Abernathy, Morgan E et al. 2021. "Sequential immunization of macaques elicits heterologous neutralizing antibodies targeting the V3-glycan patch of HIV-1 Env." Science Translational Medicine, 13 (621).

Version: Author's final manuscript

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