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dc.contributor.authorForte, Barbara
dc.contributor.authorOttilie, Sabine
dc.contributor.authorPlater, Andrew
dc.contributor.authorCampo, Brice
dc.contributor.authorDechering, Koen J
dc.contributor.authorGamo, Francisco Javier
dc.contributor.authorGoldberg, Daniel E
dc.contributor.authorIstvan, Eva S
dc.contributor.authorLee, Marcus
dc.contributor.authorLukens, Amanda K
dc.contributor.authorMcNamara, Case W
dc.contributor.authorNiles, Jacquin C
dc.contributor.authorOkombo, John
dc.contributor.authorPasaje, Charisse Flerida A
dc.contributor.authorSiegel, Miles G
dc.contributor.authorWirth, Dyann
dc.contributor.authorWyllie, Susan
dc.contributor.authorFidock, David A
dc.contributor.authorBaragaña, Beatriz
dc.contributor.authorWinzeler, Elizabeth A
dc.contributor.authorGilbert, Ian H
dc.date.accessioned2023-02-06T15:29:46Z
dc.date.available2023-02-06T15:29:46Z
dc.date.issued2021
dc.identifier.urihttps://hdl.handle.net/1721.1/147890
dc.description.abstractThere is a shift in antimalarial drug discovery from phenotypic screening toward target-based approaches, as more potential drug targets are being validated in Plasmodium species. Given the high attrition rate and high cost of drug discovery, it is important to select the targets most likely to deliver progressible drug candidates. In this paper, we describe the criteria that we consider important for selecting targets for antimalarial drug discovery. We describe the analysis of a number of drug targets in the Malaria Drug Accelerator (MalDA) pipeline, which has allowed us to prioritize targets that are ready to enter the drug discovery process. This selection process has also highlighted where additional data are required to inform target progression or deprioritization of other targets. Finally, we comment on how additional drug targets may be identified.en_US
dc.language.isoen
dc.publisherAmerican Chemical Society (ACS)en_US
dc.relation.isversionof10.1021/ACSINFECDIS.1C00322en_US
dc.rightsCreative Commons Attribution 4.0 International licenseen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.sourceACSen_US
dc.titlePrioritization of Molecular Targets for Antimalarial Drug Discoveryen_US
dc.typeArticleen_US
dc.identifier.citationForte, Barbara, Ottilie, Sabine, Plater, Andrew, Campo, Brice, Dechering, Koen J et al. 2021. "Prioritization of Molecular Targets for Antimalarial Drug Discovery." ACS Infectious Diseases, 7 (10).
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.relation.journalACS Infectious Diseasesen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2023-02-06T15:21:57Z
dspace.orderedauthorsForte, B; Ottilie, S; Plater, A; Campo, B; Dechering, KJ; Gamo, FJ; Goldberg, DE; Istvan, ES; Lee, M; Lukens, AK; McNamara, CW; Niles, JC; Okombo, J; Pasaje, CFA; Siegel, MG; Wirth, D; Wyllie, S; Fidock, DA; Baragaña, B; Winzeler, EA; Gilbert, IHen_US
dspace.date.submission2023-02-06T15:22:01Z
mit.journal.volume7en_US
mit.journal.issue10en_US
mit.licensePUBLISHER_CC
mit.metadata.statusAuthority Work and Publication Information Neededen_US


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