Show simple item record

dc.contributor.authorFinnie, Peter SB
dc.contributor.authorKomorowski, Robert W
dc.contributor.authorBear, Mark F
dc.date.accessioned2023-03-23T18:37:05Z
dc.date.available2023-03-23T18:37:05Z
dc.date.issued2021
dc.identifier.urihttps://hdl.handle.net/1721.1/148688
dc.description.abstractThe hippocampus and neocortex are theorized to be crucial partners in the formation of long-term memories. Here, we assess hippocampal involvement in two related forms of experience-dependent plasticity in the primary visual cortex (V1) of mice. Like control animals, those with hippocampal lesions exhibit potentiation of visually evoked potentials after passive daily exposure to a phase-reversing oriented grating stimulus, which is accompanied by long-term habituation of a reflexive behavioral response. Thus, low-level recognition memory is formed independently of the hippocampus. However, response potentiation resulting from daily exposure to a fixed sequence of four oriented gratings is severely impaired in mice with hippocampal damage. A feature of sequence plasticity in V1 of controls, which is absent in lesioned mice, is the generation of predictive responses to an anticipated stimulus element when it is withheld or delayed. Thus, the hippocampus is involved in encoding temporally structured experience, even within the primary sensory cortex.en_US
dc.language.isoen
dc.publisherElsevier BVen_US
dc.relation.isversionof10.1016/J.CUB.2021.06.079en_US
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs Licenseen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.sourcePMCen_US
dc.titleThe spatiotemporal organization of experience dictates hippocampal involvement in primary visual cortical plasticityen_US
dc.typeArticleen_US
dc.identifier.citationFinnie, Peter SB, Komorowski, Robert W and Bear, Mark F. 2021. "The spatiotemporal organization of experience dictates hippocampal involvement in primary visual cortical plasticity." Current Biology, 31 (18).
dc.contributor.departmentMassachusetts Institute of Technology. Department of Brain and Cognitive Sciencesen_US
dc.relation.journalCurrent Biologyen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2023-03-23T18:08:11Z
dspace.orderedauthorsFinnie, PSB; Komorowski, RW; Bear, MFen_US
dspace.date.submission2023-03-23T18:08:13Z
mit.journal.volume31en_US
mit.journal.issue18en_US
mit.licensePUBLISHER_CC
mit.metadata.statusAuthority Work and Publication Information Neededen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record