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dc.contributor.authorBhattacharya, Sayak
dc.contributor.authorDonoghue, Jacob A
dc.contributor.authorMahnke, Meredith
dc.contributor.authorBrincat, Scott L
dc.contributor.authorBrown, Emery N
dc.contributor.authorMiller, Earl K
dc.date.accessioned2023-03-27T11:39:33Z
dc.date.available2023-03-27T11:39:33Z
dc.date.issued2022
dc.identifier.urihttps://hdl.handle.net/1721.1/148762
dc.description.abstract<jats:title>Abstract</jats:title> <jats:p>Oscillatory dynamics in cortex seem to organize into traveling waves that serve a variety of functions. Recent studies show that propofol, a widely used anesthetic, dramatically alters cortical oscillations by increasing slow-delta oscillatory power and coherence. It is not known how this affects traveling waves. We compared traveling waves across the cortex of non-human primates before, during, and after propofol-induced loss of consciousness (LOC). After LOC, traveling waves in the slow-delta (∼1 Hz) range increased, grew more organized, and traveled in different directions relative to the awake state. Higher frequency (8–30 Hz) traveling waves, by contrast, decreased, lost structure, and switched to directions where the slow-delta waves were less frequent. The results suggest that LOC may be due, in part, to increases in the strength and direction of slow-delta traveling waves that, in turn, alter and disrupt traveling waves in the higher frequencies associated with cognition.</jats:p>en_US
dc.language.isoen
dc.publisherMIT Press - Journalsen_US
dc.relation.isversionof10.1162/JOCN_A_01856en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourceMIT Pressen_US
dc.titlePropofol Anesthesia Alters Cortical Traveling Wavesen_US
dc.typeArticleen_US
dc.identifier.citationBhattacharya, Sayak, Donoghue, Jacob A, Mahnke, Meredith, Brincat, Scott L, Brown, Emery N et al. 2022. "Propofol Anesthesia Alters Cortical Traveling Waves." Journal of Cognitive Neuroscience, 34 (7).
dc.contributor.departmentMassachusetts Institute of Technology. Department of Brain and Cognitive Sciencesen_US
dc.relation.journalJournal of Cognitive Neuroscienceen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2023-03-24T16:15:31Z
dspace.orderedauthorsBhattacharya, S; Donoghue, JA; Mahnke, M; Brincat, SL; Brown, EN; Miller, EKen_US
dspace.date.submission2023-03-24T16:15:33Z
mit.journal.volume34en_US
mit.journal.issue7en_US
mit.licensePUBLISHER_POLICY
mit.metadata.statusAuthority Work and Publication Information Neededen_US


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