Anterior thalamic circuits crucial for working memory
Author(s)
Roy, Dheeraj S; Zhang, Ying; Aida, Tomomi; Shen, Chenjie; Skaggs, Keith M; Hou, Yuanyuan; Fleishman, Morgan; Mosto, Olivia; Weninger, Alyssa; Feng, Guoping; ... Show more Show less
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Show full item recordAbstract
<jats:title>Significance</jats:title>
<jats:p>Anterior thalamus exhibits significant functional changes with increasing age. While it has been associated with cognitive functions, the specific circuitry relevant for working memory remains unknown. The significance of this study is threefold: First, the anteroventral subdivision of anterior thalamic nuclei is necessary for working memory maintenance; second, aged mice showed a decrease in the excitability of anteroventral thalamic neurons, which correlated with a working memory impairment; and third, activating anteroventral thalamic neurons in aged mice was sufficient to improve their working memory.</jats:p>
Date issued
2022Department
Massachusetts Institute of Technology. Department of Brain and Cognitive SciencesJournal
Proceedings of the National Academy of Sciences of the United States of America
Publisher
Proceedings of the National Academy of Sciences
Citation
Roy, Dheeraj S, Zhang, Ying, Aida, Tomomi, Shen, Chenjie, Skaggs, Keith M et al. 2022. "Anterior thalamic circuits crucial for working memory." Proceedings of the National Academy of Sciences of the United States of America, 119 (20).
Version: Final published version