Histone Deacetylases 1 and 2 in Memory Function

Author(s)
Pao, Ping-Chieh; Tsai, Li-Huei
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Abstract
Histone deacetylases (HDACs) have been implicated in learning and memory, and their dysregulation has been linked to cognitive impairment in brain aging and neurodegenerative diseases. In this review, we focus on HDAC1 and HDAC2, highlighting recent progress on their roles in regulating brain function through distinct mechanisms, including gene repression and DNA repair pathways. Moreover, we discuss evidence demonstrating how HDAC1 and HDAC2 could be modulated and their potential as targets to combat memory deficits.
Date issued
2022
URI
https://hdl.handle.net/1721.1/150472
Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Journal
ACS Chemical Neuroscience
Publisher
American Chemical Society (ACS)
Citation
Pao, Ping-Chieh and Tsai, Li-Huei. 2022. "Histone Deacetylases 1 and 2 in Memory Function." ACS Chemical Neuroscience, 13 (7).
Version: Author's final manuscript
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