Brainstem control of vocalization and its coordination with respiration
Name
Jaehong & Fan.pdf
Size
13.43 MB
Format
Adobe PDF
Checksum (MD5)
914cf0897cfa2c1b30f6230b35468cf5
Author(s)
Park, Jaehong
Choi, Seonmi
Takatoh, Jun
Zhao, Shengli
Harrahill, Andrew
Han, Bao-Xia
Wang, Fan
Date Issued
February 7, 2024
Journal
Science
Publisher
American Association for the Advancement of Science
Citation
Park, Jaehong, Choi, Seonmi, Takatoh, Jun, Zhao, Shengli, Harrahill, Andrew et al. 2024. "Brainstem control of vocalization and its coordination with respiration." Science.
Version
Author's final manuscript
Abstract
Phonation critically depends on precise controls of laryngeal muscles in coordination with ongoing respiration. However, the neural mechanisms governing these processes remain unclear. We identified excitatory vocalization-specific laryngeal premotor neurons located in the retroambiguus nucleus (RAmVOC) in adult mice as both necessary and sufficient for driving vocal cord closure and eliciting mouse ultrasonic vocalizations (USVs). The duration of RAmVOC activation can determine the lengths of both USV syllables and concurrent expiration periods, with the impact of RAmVOC-activation depending on respiration phases. RAmVOC-neurons receive inhibition from the preBötzinger complex, and inspiration-needs override RAmVOC-mediated vocal-cord closure. Ablating inhibitory synapses in RAmVOC-neurons compromised this inspiration gating of laryngeal adduction, resulting in discoordination of vocalization with respiration. Our study revealed the circuits for vocal production and vocal-respiratory coordination.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Terms of Use
Creative Commons Attribution-Noncommercial-ShareAlike
Persistent DSpace Link
