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dc.contributor.authorPark, Clara
dc.contributor.authorSingh, Manisha
dc.contributor.authorSaeed, Mossab Y.
dc.contributor.authorNguyen, Christopher T.
dc.contributor.authorRoche, Ellen T.
dc.date.accessioned2024-04-08T17:35:37Z
dc.date.available2024-04-08T17:35:37Z
dc.date.issued2024-01
dc.identifier.issn2666-9986
dc.identifier.urihttps://hdl.handle.net/1721.1/154095
dc.description.abstractIn this work, we developed a high-fidelity beating heart simulator that provides accurate mitral valve pathophysiology. The benchtop platform is based on a biorobotic hybrid heart that combines preserved intracardiac tissue with soft robotic cardiac muscle providing dynamic left ventricular motion and precise anatomical features designed for testing intracardiac devices, particularly for mitral valve repair. The heart model is integrated into a mock circulatory loop, and the active myocardium drives fluid circulation producing physiological hemodynamics without an external pulsatile pump. Using biomimetic soft robotic technology, the heart can replicate both ventricular and septal wall motion, as well as intraventricular pressure-volume relationships. This enables the system to recreate the natural motion and function of the mitral valve, which allows us to demonstrate various surgical and interventional techniques. The biorobotic cardiovascular simulator allows for real-time hemodynamic data collection, direct visualization of the intracardiac procedure, and compatibility with clinical imaging modalities.en_US
dc.language.isoen
dc.publisherElsevier BVen_US
dc.relation.isversionof10.1016/j.device.2023.100217en_US
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs Licenseen_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.sourceElsevier BVen_US
dc.titleBiorobotic hybrid heart as a benchtop cardiac mitral valve simulatoren_US
dc.typeArticleen_US
dc.identifier.citationPark, Clara, Singh, Manisha, Saeed, Mossab Y., Nguyen, Christopher T. and Roche, Ellen T. 2024. "Biorobotic hybrid heart as a benchtop cardiac mitral valve simulator." Device, 2 (1).
dc.contributor.departmentMassachusetts Institute of Technology. Institute for Medical Engineering & Science
dc.contributor.departmentMassachusetts Institute of Technology. Department of Mechanical Engineering
dc.relation.journalDeviceen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2024-04-08T17:27:43Z
dspace.orderedauthorsPark, C; Singh, M; Saeed, MY; Nguyen, CT; Roche, ETen_US
dspace.date.submission2024-04-08T17:27:46Z
mit.journal.volume2en_US
mit.journal.issue1en_US
mit.licensePUBLISHER_CC
mit.metadata.statusAuthority Work and Publication Information Neededen_US


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