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Shedding Light on Chemoresistance: The Perspective of Photodynamic Therapy in Cancer Management

Author(s)
Viana Cabral, Fernanda; Quilez Alburquerque, Jose; Roberts, Harrison James; Hasan, Tayyaba
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Abstract
The persistent failure of standard chemotherapy underscores the urgent need for innovative and targeted approaches in cancer treatment. Photodynamic therapy (PDT) has emerged as a promising photochemistry-based approach to address chemoresistance in cancer regimens. PDT not only induces cell death but also primes surviving cells, enhancing their susceptibility to subsequent therapies. This review explores the principles of PDT and discusses the concept of photodynamic priming (PDP), which augments the effectiveness of treatments like chemotherapy. Furthermore, the integration of nanotechnology for precise drug delivery at the right time and location and PDT optimization are examined. Ultimately, this study highlights the potential and limitations of PDT and PDP in cancer treatment paradigms, offering insights into future clinical applications.
Date issued
2024-03-29
URI
https://hdl.handle.net/1721.1/154126
Department
Harvard University--MIT Division of Health Sciences and Technology
Journal
International Journal of Molecular Sciecnes
Publisher
MDPI AG
Citation
Viana Cabral F, Quilez Alburquerque J, Roberts HJ, Hasan T. Shedding Light on Chemoresistance: The Perspective of Photodynamic Therapy in Cancer Management. International Journal of Molecular Sciences. 2024; 25(7):3811.
Version: Final published version
ISSN
1422-0067
Keywords
Inorganic Chemistry, Organic Chemistry, Physical and Theoretical Chemistry, Computer Science Applications, Spectroscopy, Molecular Biology, General Medicine, Catalysis

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