Show simple item record

dc.contributor.authorField, Rachel D
dc.contributor.authorJakus, Margaret A
dc.contributor.authorChen, Xiaoyu
dc.contributor.authorHuman, Kelia
dc.contributor.authorZhao, Xuanhe
dc.contributor.authorChitnis, Parag V
dc.contributor.authorSia, Samuel K
dc.date.accessioned2024-05-10T16:13:17Z
dc.date.available2024-05-10T16:13:17Z
dc.date.issued2022-05-09
dc.identifier.urihttps://hdl.handle.net/1721.1/154913
dc.description.abstractTraditional implanted drug delivery systems cannot easily change their release profile in real time to respond to physiological changes. Here we present a microfluidic aqueous two‐phase system to generate microcapsules that can release drugs on demand as triggered by focused ultrasound (FUS). The biphasic microcapsules are made of hydrogels with an outer phase of mixed molecular weight (MW) poly(ethylene glycol) diacrylate that mitigates premature payload release and an inner phase of high MW dextran with payload that breaks down in response to FUS. Compound release from microcapsules could be triggered as desired; 0.4 μg of payload was released across 16 on‐demand steps over days. We detected broadband acoustic signals amidst low heating, suggesting inertial cavitation as a key mechanism for payload release. Overall, FUS‐responsive microcapsules are a biocompatible and wirelessly triggerable structure for on‐demand drug delivery over days to weeks.en_US
dc.language.isoen
dc.publisherWileyen_US
dc.relation.isversionof10.1002/ange.202116515en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alikeen_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/en_US
dc.sourceWileyen_US
dc.titleUltrasound‐Responsive Aqueous Two‐Phase Microcapsules for On‐Demand Drug Releaseen_US
dc.typeArticleen_US
dc.identifier.citationField, Rachel D, Jakus, Margaret A, Chen, Xiaoyu, Human, Kelia, Zhao, Xuanhe et al. 2022. "Ultrasound‐Responsive Aqueous Two‐Phase Microcapsules for On‐Demand Drug Release." Angewandte Chemie, 134 (20).
dc.contributor.departmentMassachusetts Institute of Technology. Department of Mechanical Engineeringen_US
dc.relation.journalAngewandte Chemieen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2024-05-10T16:10:53Z
dspace.orderedauthorsField, RD; Jakus, MA; Chen, X; Human, K; Zhao, X; Chitnis, PV; Sia, SKen_US
dspace.date.submission2024-05-10T16:10:55Z
mit.journal.volume134en_US
mit.journal.issue20en_US
mit.licenseOPEN_ACCESS_POLICY
mit.metadata.statusAuthority Work and Publication Information Neededen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record