Activated Metals to Generate Heat for Biomedical Applications
Author(s)
Remlova, Eva; Feig, Vivian Rachel; Kang, Ziliang; Patel, Ashka; Ballinger, Ian; Ginzburg, Anna; Kuosmanen, Johannes; Fabian, Niora; Ishida, Keiko; Jenkins, Joshua; Hayward, Alison; Traverso, Giovanni; ... Show more Show less
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Delivering heat in vivo could enhance a wide range of biomedical therapeutic and diagnostic technologies, including long-term drug delivery devices and cancer treatments. To date, providing thermal energy is highly power-intensive, rendering it oftentimes inaccessible outside of clinical settings. We developed an in vivo heating method based on the exothermic reaction between liquid-metal-activated aluminum and water. After establishing a method for consistent activation, we characterized the heat generation capabilities with thermal imaging and heat flux measurements. We then demonstrated one application of this reaction: to thermally actuate a gastric resident device made from a shape-memory alloy called Nitinol. Finally, we highlight the advantages and future directions for leveraging this novel in situ heat generation method beyond the showcased example.
Date issued
2023-08-16Department
Koch Institute for Integrative Cancer Research at MIT; Massachusetts Institute of Technology. Department of Mechanical Engineering; Massachusetts Institute of Technology. Department of Mechanical Engineering; Massachusetts Institute of Technology. Division of Comparative MedicineJournal
ACS Materials Letters
Publisher
American Chemical Society
Citation
ACS Materials Lett. 2023, 5, 9, 2508–2517
Version: Final published version
ISSN
2639-4979
2639-4979