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Dynamic omnidirectional adhesive microneedle system for oral macromolecular drug delivery

Author(s)
Chen, Wei; Wainer, Jacob; Ryoo, Si Won; Qi, Xiaoyue; Chang, Rong; Li, Jason; Lee, Seung Ho; Min, Seokkee; Wentworth, Adam; Collins, Joy E.; Tamang, Siddartha; Ishida, Keiko; Hayward, Alison; Langer, Robert; Traverso, Giovanni; ... Show more Show less
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Abstract
Oral drug administration remains the preferred route for patients and health care providers. Delivery of macromolecules through this route remains challenging because of limitations imposed by the transport across the gastrointestinal epithelium and the dynamic and degradative environment. Here, we present the development of a delivery system that combines physical (microneedle) and nonphysical (enhancer) modes of drug delivery enhancement for a macromolecule in a large animal model. Inspired by the thorny-headed intestinal worm, we report a dynamic omnidirectional mucoadhesive microneedle system capable of prolonged gastric mucosa fixation. Moreover, we incorporate sodium N-[8-(2-hydroxybenzoyl) amino] caprylate along with semaglutide and demonstrate enhanced absorption in swine resistant to physical displacement in the gastric cavity. Meanwhile, we developed a targeted capsule system capable of deploying intact microneedle-containing systems. These systems stand to enable the delivery of a range of drugs through the generation and maintenance of a privileged region in the gastrointestinal tract.
Date issued
2022-01-07
URI
https://hdl.handle.net/1721.1/155046
Department
Massachusetts Institute of Technology. Department of Mechanical Engineering; Koch Institute for Integrative Cancer Research at MIT; Massachusetts Institute of Technology. Division of Comparative Medicine; Massachusetts Institute of Technology. Department of Chemical Engineering
Journal
Science Advances
Publisher
American Association for the Advancement of Science
Citation
Wei Chen et al. ,Dynamic omnidirectional adhesive microneedle system for oral macromolecular drug delivery.Sci. Adv.8,eabk1792(2022).
Version: Final published version
ISSN
2375-2548

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