Polyanhydride-Based Microparticles for Programmable Pulsatile Release of Diphtheria Toxoid (DT) for Single-Injection Self-Boosting Vaccines

Abstract

Single‐Injection Self‐Boosting Vaccines A single‐injection platform for self‐boosting vaccines is developed using a polyanhydride‐based delivery system. The platform enables pulsatile antigen release, protects pH‐sensitive cargo, and elicits immune responses comparable to traditional multi‐dose regimens. Machine learning enhances design by accurately predicting release profiles, offering a promising solution to improve global vaccine coverage and reduce under‐immunization. More details can be found in article number 2501168 by Robert Langer, Ana Jaklenec, and co‐workers.