| dc.contributor.author | Chua, Corrine Ying Xuan | |
| dc.contributor.author | Jiang, Allen Yujie | |
| dc.contributor.author | Eufrásio-da-Silva, Tatiane | |
| dc.contributor.author | Dolatshahi-Pirouz, Alireza | |
| dc.contributor.author | Langer, Robert | |
| dc.contributor.author | Orive, Gorka | |
| dc.contributor.author | Grattoni, Alessandro | |
| dc.date.accessioned | 2025-10-17T20:30:54Z | |
| dc.date.available | 2025-10-17T20:30:54Z | |
| dc.date.issued | 2023-03 | |
| dc.identifier.uri | https://hdl.handle.net/1721.1/163219 | |
| dc.description.abstract | Cellular therapies are poised to transform the field of medicine by restoring dysfunctional tissues and treating various diseases in a dynamic manner not achievable by conventional pharmaceutics. Spanning various therapeutic areas inclusive of cancer, regenerative medicine, and immune disorders, cellular therapies comprise stem or non-stem cells derived from various sources. Despite numerous clinical approvals or trials underway, the host immune response presents a critical impediment to the widespread adoption and success of cellular therapies. Here, we review current research and clinical advances in immunomodulatory strategies to mitigate immune rejection or promote immune tolerance to cellular therapies. We discuss the potential of these immunomodulatory interventions to accelerate translation or maximize the prospects of improving therapeutic outcomes of cellular therapies for clinical success. | en_US |
| dc.language.iso | en | |
| dc.publisher | Elsevier BV | en_US |
| dc.relation.isversionof | 10.1016/j.tibtech.2022.11.008 | en_US |
| dc.rights | Creative Commons Attribution-NonCommercial-NoDerivatives | en_US |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | en_US |
| dc.source | Elsevier BV | en_US |
| dc.title | Emerging immunomodulatory strategies for cell therapeutics | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Chua, Corrine Ying Xuan, Jiang, Allen Yujie, Eufrásio-da-Silva, Tatiane, Dolatshahi-Pirouz, Alireza, Langer, Robert et al. 2023. "Emerging immunomodulatory strategies for cell therapeutics." Trends in Biotechnology, 41 (3). | |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Chemical Engineering | en_US |
| dc.contributor.department | Koch Institute for Integrative Cancer Research at MIT | en_US |
| dc.relation.journal | Trends in Biotechnology | en_US |
| dc.eprint.version | Final published version | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dc.date.updated | 2025-10-17T19:50:26Z | |
| dspace.orderedauthors | Chua, CYX; Jiang, AY; Eufrásio-da-Silva, T; Dolatshahi-Pirouz, A; Langer, R; Orive, G; Grattoni, A | en_US |
| dspace.date.submission | 2025-10-17T19:50:28Z | |
| mit.journal.volume | 41 | en_US |
| mit.journal.issue | 3 | en_US |
| mit.license | PUBLISHER_CC | |
| mit.metadata.status | Authority Work and Publication Information Needed | en_US |
