Browsing MIT Open Access Articles by Author "Earl, Ashlee M."

Now showing items 1-2 of 2

    • Clinically relevant mutations in core metabolic genes confer antibiotic resistance 

      Lopatkin, Allison J.; Bening, Sarah C.; Manson, Abigail L.; Stokes, Jonathan M.; Kohanski, Michael A.; e.a. (American Association for the Advancement of Science (AAAS), 2021-02)
      © 2021 American Association for the Advancement of Science. All rights reserved. Although metabolism plays an active role in antibiotic lethality, antibiotic resistance is generally associated with drug target modification, ...

    • Discovery of a structural class of antibiotics with explainable deep learning 

      Wong, Felix; Zheng, Erica J.; Valeri, Jacqueline A.; Donghia, Nina M.; Anahtar, Melis N.; e.a. (Springer Nature, 2023-12-20)
      The discovery of novel structural classes of antibiotics is urgently needed to address the ongoing antibiotic resistance crisis. Deep learning approaches have aided in exploring chemical spaces; these typically use black ...