Browsing MIT Open Access Articles by Author "East, Philip"
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Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth
Griffiths, Beatrice; Lewis, Caroline A; Bensaad, Karim; Ros, Susana; Zhang, Qifeng; e.a. (BioMed Central Ltd., 2013-01)Background: Regulation of lipid metabolism via activation of sterol regulatory element binding proteins (SREBPs) has emerged as an important function of the Akt/mTORC1 signaling axis. Although the contribution of dysregulated ...