Browsing MIT Open Access Articles by Author "Eaton, Matthew Lucas"

Now showing items 1-4 of 4

    • Alzheimer's loci: epigenetic associations and interaction with genetic factors 

      Chibnik, Lori B.; Yu, Lei; Srivastava, Gyan; Schneider, Julie A.; Kellis, Manolis; e.a. (American Neurological Association, 2015-04)
      Objective We explore the role of DNA methylation in Alzheimer's disease (AD). To elucidate where DNA methylation falls along the causal pathway linking risk factors to disease, we examine causal models to assess its role ...

    • BRCA1 Recruitment to Transcriptional Pause Sites Is Required for R-Loop-Driven DNA Damage Repair 

      Hatchi, Elodie; Skourti-Stathaki, Konstantina; Ventz, Steffen; Pinello, Luca; Yen, Angela; e.a. (Elsevier, 2015-02)
      The mechanisms contributing to transcription-associated genomic instability are both complex and incompletely understood. Although R-loops are normal transcriptional intermediates, they are also associated with genomic ...

    • An integrated encyclopedia of DNA elements in the human genome 

      Altshuler, Robert Charles; Ernst, Jason; Kellis, Manolis; Kheradpour, Pouya; Ward, Lucas D.; e.a. (Nature Publishing Group, 2012-09)
      The human genome encodes the blueprint of life, but the function of the vast majority of its nearly three billion bases is unknown. The Encyclopedia of DNA Elements (ENCODE) project has systematically mapped regions of ...

    • Integrative analysis of 111 reference human epigenomes 

      Kundaje, Anshul; Meuleman, Wouter; Ernst, Jason; Yen, Angela; Kheradpour, Pouya; e.a. (Nature Publishing Group, 2015-02)
      The reference human genome sequence set the stage for studies of genetic variation and its association with human disease, but epigenomic studies lack a similar reference. To address this need, the NIH Roadmap Epigenomics ...