Browsing MIT Open Access Articles by Subject "AAA+ protease"
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Degrons in Protein Substrates Program the Speed and Operating Efficiency of the AAA+ Lon Proteolytic Machine
(National Academy of Sciences (U.S.), 2009-10)AAA+ proteases are ATP-fueled machines that bind protein substrates via a degradation tag, unfold the molecule if necessary, and then translocate the polypeptide into a chamber for proteolysis. Tag recognition is normally ...