Browsing MIT Open Access Articles by Subject "Biochemistry"
Now showing items 1-20 of 21
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Bifunctional diazirine reagent for covalent dyeing of Kevlar and inert polymer materials
(Royal Society of Chemistry, 2023)We report a convenient bifunctional diazirine reagent that is capable of photochemically modifying inert polymers, particularly those used in fibers and textiles for ballistics and blast protective gear, such as para-aramid ... -
Catalytic, contra-Thermodynamic Positional Alkene Isomerization
(American Chemical Society (ACS), 2021-12)The positional isomerization of C═C double bonds is a powerful strategy for the interconversion of alkene regioisomers. However, existing methods provide access to thermodynamically more stable isomers from less stable ... -
Chemical Biology Framework to Illuminate Proteostasis
(Annual Reviews, 2020-06)© 2020 Annual Reviews Inc.. All rights reserved. Protein folding in the cell is mediated by an extensive network of >1,000 chaperones, quality control factors, and trafficking mechanisms collectively termed the proteostasis ... -
Collagen Prolyl Hydroxylases Are Bifunctional Growth Regulators in Melanoma
(Elsevier Science Ltd., 2018-11-16)Appropriate post-translational processing of collagen requires prolyl hydroxylation, catalyzed by collagen prolyl 3-hydroxylase and collagen prolyl 4-hydroxylase, and is essential for normal cell function. Here we have ... -
Design, Characterization, and Preliminary Assessment of a Two-Degree-of-Freedom Powered Ankle–Foot Prosthesis
(MDPI AG, 2024-01-26)Powered ankle prostheses have been proven to improve the walking economy of people with transtibial amputation. All commercial powered ankle prostheses that are currently available can only perform one-degree-of-freedom ... -
Development of a perfusable, hierarchical microvasculature-on-a-chip model
(Royal Society of Chemistry, 2023)Several methods have been developed for generating 3D, in vitro, organ-on-chip models of human vasculature to study vascular function, transport, and tissue engineering. However, many of these existing models lack the ... -
DNA Intercalation Facilitates Efficient DNA-Targeted Covalent Binding of Phenanthriplatin
(American Chemical Society (ACS), 2019-01-02)Phenanthriplatin, a monofunctional anticancer agent derived from cisplatin, shows significantly more rapid DNA covalent-binding activity compared to its parent complex. To understand the underlying molecular mechanism, we ... -
Driving Recursive Dehydration by PIII/PV Catalysis: Annulation of Amines and Carboxylic Acids by Sequential C–N and C–C Bond Formation
(American Chemical Society (ACS), 2019-07-25)A method for the annulation of amines and carboxylic acids to form pharmaceutically relevant azaheterocycles via organophosphorus PIII/PV redox catalysis is reported. The method employs a phosphetane catalyst together with ... -
Enantioselective Allylation Using Allene, a Petroleum Cracking Byproduct
(American Chemical Society (ACS), 2019-01-27)Allene (C₃H₄) gas is produced and separated on million-metric-ton scale per year during petroleum refining but is rarely employed in organic synthesis. Meanwhile, the addition of an allyl group (C₃H₅) to ketones is among ... -
Enantioselective synthesis of (-)-vallesine: late-stage C17-oxidation via complex indole boronation
(American Chemical Society (ACS), 2018-06)The first enantioselective total synthesis of (-)-vallesine via a strategy that features a late-stage regioselective C17-oxidation followed by a highly stereoselective transannular cyclization is reported. The versatility ... -
Enzyme Pretreatment plus Locally Delivered HB-IGF-1 Stimulate Integrative Cartilage Repair In Vitro
(Mary Ann Liebert Inc, 2019-09-01)Focal cartilage defects caused by joint injury have a limited capacity to self-repair and, if left untreated, can lead to the early onset of osteoarthritis. The current standard of care, microfracture surgery, induces an ... -
Histidine N(τ)-cyclized macrocycles as a new genre of polo-like kinase 1 polo-box domain-binding inhibitors
(Elsevier BV, 2018-10)Transition toward peptide mimetics of reduced size is an important objective of peptide macrocyclization. We have previously shown that PLH∗SpT (2a) (where H∗ indicates the presence of a –(CH2)8Ph group at the N(π) position ... -
Impact of DNA lesion repair, replication and formation on the mutational spectra of environmental carcinogens: Aflatoxin B1 as a case study
(Elsevier BV, 2018-11)In a multicellular organism, somatic mutations represent a permanent record of the past chemical and biochemical perturbations experienced by a cell in its local microenvironment. Akin to a perpetual recording device, with ... -
Intermittent actuation attenuates fibrotic behaviour of myofibroblasts
(Elsevier BV, 2024-01)The foreign body response (FBR) to implanted materials culminates in the deposition of a hypo-permeable, collagen rich fibrotic capsule by myofibroblast cells at the implant site. The fibrotic capsule can be deleterious ... -
Learned features of antibody-antigen binding affinity
(Frontiers Media SA, 2023-02-21)<jats:p>Defining predictors of antigen-binding affinity of antibodies is valuable for engineering therapeutic antibodies with high binding affinity to their targets. However, this task is challenging owing to the huge ... -
Leveraging the Sensitivity of Plants with Deep Learning to Recognize Human Emotions
(MDPI AG, 2024-03-16)Recent advances in artificial intelligence combined with behavioral sciences have led to the development of cutting-edge tools for recognizing human emotions based on text, video, audio, and physiological data. However, ... -
Monoamine Biosynthesis via a Noncanonical Calcium-Activatable Aromatic Amino Acid Decarboxylase in Psilocybin Mushroom
(American Chemical Society (ACS), 2018-11-28)Aromatic l-amino acid decarboxylases (AAADs) are a phylogenetically diverse group of enzymes responsible for the decarboxylation of aromatic amino acid substrates into their corresponding aromatic arylalkylamines. AAADs ... -
PGE2 in fibrosis and cancer: Insights into fibroblast activation
(Elsevier BV, 2019-08) -
Scalable mesenchymal stem cell enrichment from bone marrow aspirate using deterministic lateral displacement (DLD) microfluidic sorting
(Royal Society of Chemistry, 2023)The growing interest in regenerative medicine has opened new avenues for novel cell therapies using stem cells. Bone marrow aspirate (BMA) is an important source of stromal mesenchymal stem cells (MSCs). Conventional MSC ... -
Spatial Exclusivity Combined with Positive and Negative Selection of Phosphorylation Motifs Is the Basis for Context-Dependent Mitotic Signaling
(American Association for the Advancement of Science (AAAS), 2011-06-28)The timing and localization of events during mitosis are controlled by the regulated phosphorylation of proteins by the mitotic kinases, which include Aurora A, Aurora B, Nek2 (never in mitosis kinase 2), Plk1 (Polo-like ...