Browsing MIT Open Access Articles by Subject "T helper differentiation"
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The Transcription Factors T-bet and GATA-3 Control Alternative Pathways of T-cell Differentiation Through a Shared Set of Target Genes
(National Academy of Sciences (U.S.), 2009-10)Upon detection of antigen, CD4+ T helper (Th) cells can differentiate into a number of effector types that tailor the immune response to different pathogens. Alternative Th1 and Th2 cell fates are specified by the transcription ...