Search
Now showing items 1-2 of 2
Identification of cell cycle-targeting microRNAs through genome-wide screens
(Informa UK Limited, 2017-11-14)
By performing nine genome-wide microRNA (miRNA) screens, we recently uncovered a new class of miRNAs, which target multiple cyclins and cyclin-dependent kinases (CDKs). Systemic delivery of selected cell cycle-targeting ...
Partial DNA-guided Cas9 enables genome editing with reduced off-target activity
(Springer Nature, 2018-01-29)
CRISPR-Cas9 is a versatile RNA-guided genome editing tool. Here we demonstrate that partial replacement of RNA nucleotides with DNA nucleotides in CRISPR RNA (crRNA) enables efficient gene editing in human cells. This ...