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TGF-β signaling in cellular senescence and aging-related pathology
(MDPI AG, 2019-10-10)
Aging is broadly defined as the functional decline that occurs in all body systems. The accumulation of senescent cells is considered a hallmark of aging and thought to contribute to the aging pathologies. Transforming ...
Gain-of-function mutation of microRNA-140 in human skeletal dysplasia
(Springer Science and Business Media LLC, 2019-02-25)
MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression. Heterozygous loss-of-function point mutations of miRNA genes are associated with several human congenital disorders 1–5 , but neomorphic ...
Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates
(eLife Sciences Publications, Ltd, 2018-05-10)
Nitrogen-containing-bisphosphonates (N-BPs) are a class of drugs widely prescribed to treat osteoporosis and other bone-related diseases. Although previous studies have established that N-BPs function by inhibiting the ...