MIT Open Access Articles: Recent submissions
Now showing items 1-3 of 32522
-
In-solution enrichment identifies peptide inhibitors of protein–protein interactions
(Springer Nature, 2019-03-18)The use of competitive inhibitors to disrupt protein–protein interactions (PPIs) holds great promise for the treatment of disease. However, the discovery of high-affinity inhibitors can be a challenge. Here we report a ... -
Catalysis of Hydrogen–Deuterium Exchange Reactions by 4-Substituted Proline Derivatives
(American Chemical Society (ACS), 2019-01)The identification and understanding of structure–activity relationships is vital for rational catalyst design. A kinetic study of the hydrogen–deuterium exchange reaction of cyclohexanone in aqueous solution, as catalyzed ... -
Blood–brain-barrier organoids for investigating the permeability of CNS therapeutics
(Springer Nature, 2018-10-31)In vitro models of the blood–brain barrier (BBB) are critical tools for the study of BBB transport and the development of drugs that can reach the CNS. Brain endothelial cells grown in culture are often used to model the ...