MIT Open Access Articles: Recent submissions
Now showing items 1-3 of 54421
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Priming agents transiently reduce the clearance of cell-free DNA to improve liquid biopsies
(American Association for the Advancement of Science, 2024-01-19)Liquid biopsies enable early detection and monitoring of diseases such as cancer, but their sensitivity remains limited by the scarcity of analytes such as cell-free DNA (cfDNA) in blood. Improvements to sensitivity have ... -
Vaccine targeting to mucosal lymphoid tissues promotes humoral immunity in the gastrointestinal tract
(American Association for the Advancement of Science, 2024-05-29)Viruses, bacteria, and parasites frequently cause infections in the gastrointestinal tract, but traditional vaccination strategies typically elicit little or no mucosal antibody responses. Here, we report a strategy to ... -
Expansion of tumor-reactive CD8+ T cell clonotypes occurs in the spleen in response to immune checkpoint blockade
(American Association for the Advancement of Science, 2024-09-13)Immune checkpoint blockade (ICB) enhances T cell responses against cancer, leading to long-term survival in a fraction of patients. CD8+ T cell differentiation in response to chronic antigen stimulation is highly complex ...