MIT Open Access Articles: Recent submissions

Now showing items 7-9 of 54578

    • Peanut oral immunotherapy differentially suppresses clonally distinct subsets of T helper cells 

      Monian, Brinda; Tu, Ang A; Ruiter, Bert; Morgan, Duncan M; Petrossian, Patrick M; e.a. (American Society for Clinical Investigation, 2021-11-23)
      Food allergy affects an estimated 8% of children in the United States. Oral immunotherapy (OIT) is a recently approved treatment, with outcomes ranging from sustained tolerance to food allergens to no apparent benefit. The ...

    • Mitochondrial variant enrichment from high-throughput single-cell RNA sequencing resolves clonal populations 

      Miller, Tyler E; Lareau, Caleb A; Verga, Julia A; DePasquale, Erica AK; Liu, Vincent; e.a. (Springer Science and Business Media LLC, 2022-02-24)
      The combination of single-cell transcriptomics with mitochondrial DNA variant detection can be used to establish lineage relationships in primary human cells, but current methods are not scalable to interrogate complex ...

    • SARS-CoV-2 receptor binding domain displayed on HBsAg virus–like particles elicits protective immunity in macaques 

      Massachusetts Institute of Technology. Department of Chemical Engineering; Koch Institute for Integrative Cancer Research at MIT; Massachusetts Institute of Technology. Department of Biological Engineering; Ragon Institute of MGH, MIT and Harvard (American Association for the Advancement of Science, 2022-03-16)
      Authorized vaccines against SARS-CoV-2 remain less available in low- and middle-income countries due to insufficient supply, high costs, and storage requirements. Global immunity could still benefit from new vaccines using ...