Assisted assembly: how to improve a de novo genome assembly by using related species
Author(s)Gnerre, Sante; Lander, Eric S.; Lindblad-Toh, Kerstin; Jaffe, David B.
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We describe a new assembly algorithm, where a genome assembly with low sequence coverage, either throughout the genome or locally, due to cloning bias, is considerably improved through an assisting process via a related genome. We show that the information provided by aligning the whole-genome shotgun reads of the target against a reference genome can be used to substantially improve the quality of the resulting assembly.
DepartmentMassachusetts Institute of Technology. Department of Biology
BioMed Central Ltd.
Gnerre, Sante et al. “Assisted assembly: how to improve a de novo genome assembly by using related species.” Genome Biology 10.8 (2009): R88.
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