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Assisted assembly: how to improve a de novo genome assembly by using related species

Author(s)
Gnerre, Sante; Lindblad-Toh, Kerstin; Jaffe, David B.; Lander, Eric Steven
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Abstract
We describe a new assembly algorithm, where a genome assembly with low sequence coverage, either throughout the genome or locally, due to cloning bias, is considerably improved through an assisting process via a related genome. We show that the information provided by aligning the whole-genome shotgun reads of the target against a reference genome can be used to substantially improve the quality of the resulting assembly.
Date issued
2009-08
URI
http://hdl.handle.net/1721.1/49466
Department
Massachusetts Institute of Technology. Department of Biology
Journal
Genome Biology
Publisher
BioMed Central Ltd.
Citation
Gnerre, Sante et al. “Assisted assembly: how to improve a de novo genome assembly by using related species.” Genome Biology 10.8 (2009): R88.
Version: Final published version
ISSN
1465-6906

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