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dc.contributor.authorGe, Xuecai
dc.contributor.authorFrank, Christopher Lee
dc.contributor.authorCalderon de Anda, Froylan
dc.contributor.authorTsai, Li-Huei
dc.date.accessioned2010-01-21T17:13:48Z
dc.date.available2010-01-21T17:13:48Z
dc.date.issued2010-01
dc.date.submitted2010
dc.identifier.issn0896-6273
dc.identifier.issn1097-4199
dc.identifier.urihttp://hdl.handle.net/1721.1/50868
dc.description.abstractCentrosome functions are important in many brain developmental processes. Proper functioning of the centrosome relies on assembly of protein components into the pericentriolar material. This dynamic assembly is mediated by the trafficking of pericentriolar satellites, which are comprised of centrosomal proteins. Here we demonstrate that trafficking of pericentriolar satellites requires the interaction between Hook3 and Pericentriolar Material 1 (PCM1). Hook3, previously shown to link the centrosome and the nucleus in C. elegans, is recruited to pericentriolar satellites through interaction with PCM1, a protein associated with schizophrenia. Knocking down of Hook3 or PCM1, or disrupting the Hook3-PCM1 interaction in vivo impairs interkinetic nuclear migration, a featured behavior of embryonic neural progenitors. This in turn leads to overproduction of neurons and premature depletion of the neural progenitor pool in the developing neocortex. These results underscore the importance of centrosomal assembly in neurogenesis, and provide potential insights into the etiology of brain developmental diseases related to centrosome dysfunction.en
dc.language.isoen_US
dc.publisherElsevieren
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.neuron.2010.01.011
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en
dc.sourceLi-Huei Tsai via Andy Devlinen
dc.titleHook3 interacts with PCM1 to regulate pericentriolar material assembly and the timing of neurogenesisen
dc.typeArticleen
dc.identifier.citationGe, Xuecai, et al. "Hook3 interacts with PCM1 to regulate pericentriolar material assembly and the timing of neurogenesis." Neuron, 65:2, 28 January 2010, Pages 191–203.en
dc.contributor.departmentMassachusetts Institute of Technology. Department of Brain and Cognitive Sciencesen_US
dc.contributor.departmentPicower Institute for Learning and Memoryen_US
dc.contributor.approverTsai, Li-Huei
dc.contributor.mitauthorGe, Xuecai
dc.contributor.mitauthorCalderon de Anda, Froylan
dc.contributor.mitauthorTsai, Li-Huei
dc.relation.journalNeuronen
dc.eprint.versionAuthor's final manuscript
dc.type.urihttp://purl.org/eprint/type/SubmittedJournalArticleen
eprint.statushttp://purl.org/eprint/status/PeerRevieweden
dspace.orderedauthorsGe, Xuecai; Frank, Christopher L.; Calderon de Anda, Froylan; Tsai, Li-Huei
dc.identifier.orcidhttps://orcid.org/0000-0003-1262-0592
mit.licensePUBLISHER_POLICYen


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