Thymic Selection of T-Cell Receptors as an Extreme Value Problem
Author(s)Kardar, Mehran; Chakraborty, Arup K.; Shaknovich, Eugene I.; Kosmrlj, Andrej
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T lymphocytes (T cells) orchestrate adaptive immune responses upon activation. T-cell activation requires sufficiently strong binding of T-cell receptors on their surface to short peptides (p) derived from foreign proteins, which are bound to major histocompatibility gene products (displayed on antigen-presenting cells). A diverse and self-tolerant T-cell repertoire is selected in the thymus. We map thymic selection processes to an extreme value problem and provide an analytic expression for the amino acid compositions of selected T-cell receptors (which enable its recognition functions).
DepartmentMassachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Chemical Engineering; Massachusetts Institute of Technology. Department of Chemistry; Massachusetts Institute of Technology. Department of Physics
Physical Review Letters
American Physical Society
Kosmrlj, Andrej et al. “Thymic Selection of T-Cell Receptors as an Extreme Value Problem.” Physical Review Letters 103.6 (2009): 068103. © 2009 The American Physical Society.
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