Internal Friction and Nonequilibrium Unfolding of Polymeric Globules
Author(s)Wada, Hirofumi; Netz, Roland R.; Alexander-Katz, Alfredo
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The stretching response of a single collapsed homopolymer is studied using Brownian dynamic simulations. The irreversibly dissipated work is found to be dominated by internal friction effects below the collapse temperature, and the internal viscosity grows exponentially with the effective cohesive strength between monomers. These results explain friction effects of globular DNA and are relevant for dissipation at intermediate stages of protein folding.
DepartmentMassachusetts Institute of Technology. Department of Materials Science and Engineering
Physical Review Letters
American Physical Society
Alexander-Katz, Alfredo , Hirofumi Wada, and Roland R. Netz. “Internal Friction and Nonequilibrium Unfolding of Polymeric Globules.” Physical Review Letters 103.2 (2009): 028102. © 2009 The American Physical Society.
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