Transdermal drug delivery by localized intervention
Author(s)Weaver, James C.; Herndon, Terry O.; Gowrishankar, Thiruvallur R.
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Both field-confined skin electroporation and microscissioning offer minimally invasive methods for delivering drugs across skin and nail with minimal sensation. Both methods create high permeability pathways in a pain-free manner. These openings are similar in dimension to commonly experienced scratches and nicks on the skin. These localized openings provide pathways for sustained delivery of drugs either passively using a patch or actively using pressure or iontophoresis.
DepartmentHarvard University--MIT Division of Health Sciences and Technology
IEEE Engineering in Medicine and Biology Magazine
Institute of Electrical and Electronics Engineers
Gowrishankar, T.R., T.O. Herndon, and J.C. Weaver. “Transdermal drug delivery by localized intervention.” Engineering in Medicine and Biology Magazine, IEEE 28.1 (2009): 55-63. © Copyright 2009 IEEE
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