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Differentiation of normal and cancerous lung tissues by multiphoton imaging

Author(s)
Wang, Chun-Chin; Li, Feng-Chieh; Wu, Ruei-Jhih; Hovhannisyan, Vladimir; Lin, Wei-Chou; Lin, Sung-Jan; So, Peter T. C.; Dong, Chen-Yuan; ... Show more Show less
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Abstract
We utilize multiphoton microscopy for the label-free diagnosis of noncancerous, lung adenocarcinoma (LAC), and lung squamous cell carcinoma (SCC) tissues from humans. Our results show that the combination of second-harmonic generation (SHG) and multiphoton excited autofluorescence (MAF) signals may be used to acquire morphological and quantitative information in discriminating cancerous from noncancerous lung tissues. Specifically, noncancerous lung tissues are largely fibrotic in structure, while cancerous specimens are composed primarily of tumor masses. Quantitative ratiometric analysis using MAF to SHG index (MAFSI) shows that the average MAFSI for noncancerous and LAC lung tissue pairs are 0.55±0.23 and 0.87±0.15, respectively. In comparison, the MAFSIs for the noncancerous and SCC tissue pairs are 0.50±0.12 and 0.72±0.13, respectively. Our study shows that nonlinear optical microscopy can assist in differentiating and diagnosing pulmonary cancer from noncancerous tissues.
Date issued
2009-08
URI
http://hdl.handle.net/1721.1/52427
Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
Journal
Journal of Biomedical Optics
Publisher
Society of Photo-Optical Instrumentation Engineers
Citation
Wang, Chun-Chin et al. “Differentiation of normal and cancerous lung tissues by multiphoton imaging.” Journal of Biomedical Optics 14.4 (2009): 044034-4. ©2009 Society of Photo-Optical Instrumentation Engineers
Version: Final published version
ISSN
1083-3668

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