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dc.contributor.authorLi, Zi Rui
dc.contributor.authorLiu, Gui Rong
dc.contributor.authorCheng, Yuan
dc.contributor.authorHan, Jongyoon
dc.contributor.authorChen, Yu Zong
dc.contributor.authorWang, Jian-Sheng
dc.contributor.authorHadjiconstantinou, Nicolas
dc.date.accessioned2010-03-11T18:21:18Z
dc.date.available2010-03-11T18:21:18Z
dc.date.issued2009-06
dc.date.submitted2009-10
dc.identifier.issn1550-2376
dc.identifier.issn1539-3755
dc.identifier.urihttp://hdl.handle.net/1721.1/52513
dc.description.abstractWe present a theoretical model describing Ogston (pore size comparable to or larger than the characteristic molecular dimension) sieving of rigid isotropic and anisotropic biomolecules in nanofluidic molecular filter arrays comprising of alternating deep and shallow regions. Starting from a quasi-one-dimensional drift-diffusion description, which captures the interplay between the driving electric force, entropic barrier and molecular diffusion, we derive explicit analytical results for the effective mobility and trapping time. Our results elucidate the effects of field strength, device geometry and entropic barrier height, providing a robust tool for the design and optimization of nanofilter/nanopore systems. Specifically, we show that Ogston sieving becomes negligible when the length of shallow region becomes sufficiently small, mainly due to efficient diffusional transport through the short shallow region. Our theoretical results are in line with experimental observations and provide important design insight for nanofluidic systems.en
dc.description.sponsorshipSingapore-MIT Alliance SMA -II, Computational Engineering CE programen
dc.language.isoen_US
dc.publisherAmerican Physical Societyen
dc.relation.isversionofhttp://dx.doi.org/10.1103/PhysRevE.80.041911en
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en
dc.sourceAPSen
dc.titleAnalytical description of Ogston-regime biomolecule separation using and nanoporesen
dc.typeArticleen
dc.identifier.citationLi, Zi Rui et al. “Analytical description of Ogston-regime biomolecule separation using nanofilters and nanopores.” Physical Review E 80.4 (2009): 041911. © 2009 The American Physical Societyen
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Electrical Engineering and Computer Scienceen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Mechanical Engineeringen_US
dc.contributor.approverHadjiconstantinou, Nicolas
dc.contributor.mitauthorHan, Jongyoon
dc.contributor.mitauthorHadjiconstantinou, Nicolas
dc.relation.journalPhysical Review Een
dc.eprint.versionFinal published versionen
dc.type.urihttp://purl.org/eprint/type/JournalArticleen
eprint.statushttp://purl.org/eprint/status/PeerRevieweden
dspace.orderedauthorsLi, Zi; Liu, Gui; Han, Jongyoon; Cheng, Yuan; Chen, Yu; Wang, Jian-Sheng; Hadjiconstantinou, Nicolasen
dc.identifier.orcidhttps://orcid.org/0000-0002-1670-2264
dc.identifier.orcidhttps://orcid.org/0000-0001-7215-1439
mit.licensePUBLISHER_POLICYen


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