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dc.contributor.authorLin, Yu-Li
dc.contributor.authorSengupta, Shomit
dc.contributor.authorGurdziel, Katherine
dc.contributor.authorBell, George W.
dc.contributor.authorJacks, Tyler E.
dc.contributor.authorFlores, Elsa R.
dc.date.accessioned2010-03-15T13:31:12Z
dc.date.available2010-03-15T13:31:12Z
dc.date.issued2009-10
dc.date.submitted2009-04
dc.identifier.issn1553-7390
dc.identifier.issn1553-7404
dc.identifier.urihttp://hdl.handle.net/1721.1/52572
dc.description.abstractThe p53 family activates many of the same genes in response to DNA damage. Because p63 and p73 have structural differences from p53 and play distinct biological functions in development and metastasis, it is likely that they activate a unique transcriptional network. Therefore, we performed a genome-wide analysis using cells lacking the p53 family members after treatment with DNA damage. We identified over 100 genes involved in multiple pathways that were uniquely regulated by p63 or p73, and not p53. Further validation indicated that BRCA2, Rad51, and mre11 are direct transcriptional targets of p63 and p73. Additionally, cells deficient for p63 and p73 are impaired in DNA repair and p63+/−;p73+/− mice develop mammary tumors suggesting a novel mechanism whereby p63 and p73 suppress tumorigenesis.en
dc.language.isoen_US
dc.publisherPublic Library of Scienceen
dc.relation.isversionofhttp://dx.doi.org/10.1371/journal.pgen.1000680en
dc.rightsCreative Commons Attributionen
dc.rights.urihttp://creativecommons.org/licenses/by/2.5/en
dc.sourcePLoSen
dc.titlep63 and p73 Transcriptionally Regulate Genes Involved in DNA Repairen
dc.typeArticleen
dc.identifier.citationLin Y-L, Sengupta S, Gurdziel K, Bell GW, Jacks T, et al. (2009) p63 and p73 Transcriptionally Regulate Genes Involved in DNA Repair. PLoS Genet 5(10): e1000680. doi:10.1371/journal.pgen.1000680en
dc.contributor.departmentBroad Institute of MIT and Harvarden_US
dc.contributor.departmentDavid H. Koch Institute for Integrative Cancer Research at MITen_US
dc.contributor.approverJacks, Tyler E.
dc.contributor.mitauthorSengupta, Shomit
dc.contributor.mitauthorGurdziel, Katherine
dc.contributor.mitauthorJacks, Tyler E.
dc.relation.journalPLoS Geneticsen
dc.eprint.versionFinal published versionen
dc.identifier.pmid19816568
dc.type.urihttp://purl.org/eprint/type/JournalArticleen
eprint.statushttp://purl.org/eprint/status/PeerRevieweden
dspace.orderedauthorsLin, Yu-Li; Sengupta, Shomit; Gurdziel, Katherine; Bell, George W.; Jacks, Tyler; Flores, Elsa R.en
dc.identifier.orcidhttps://orcid.org/0000-0001-5785-8911
mit.licensePUBLISHER_CCen


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