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dc.contributor.authorWyatt, John L.
dc.contributor.authorDrohan, William A.
dc.contributor.authorDoyle, Patrick S.
dc.contributor.authorKelly, Shawn K.
dc.contributor.authorRizzo, Joseph F., III
dc.contributor.authorCogan, Stuart F.
dc.contributor.authorTheogarajan, Luke S.
dc.contributor.authorGingerich, Marcus D.
dc.contributor.authorChen, Jinghua
dc.contributor.authorShire, Douglas B.
dc.date.accessioned2010-03-16T15:31:19Z
dc.date.available2010-03-16T15:31:19Z
dc.date.issued2009-11
dc.date.submitted2009-04
dc.identifier.isbn978-1-4244-3296-7
dc.identifier.issn1557-170X
dc.identifier.urihttp://hdl.handle.net/1721.1/52616
dc.description.abstractA miniaturized, hermetically-encased, wirelessly-operated retinal prosthesis has been developed for implantation and pre-clinical studies in Yucatan mini-pig animal models. The prosthesis conforms to the eye and drives a microfabricated polyimide stimulating electrode array with sputtered iridium oxide electrodes. This array is implanted in the subretinal space using a specially-designed ab externo surgical technique that affixes the bulk of the prosthesis to the surface of the sclera. The implanted device includes a hermetic titanium case containing a 15-channel stimulator chip and discrete power supply components. Feedthroughs from the case connect to secondary power- and data-receiving coils. In addition, long-term in vitro pulse testing was performed on the electrodes to ensure their stability for the long lifetime of the hermetic case. The final assembly was tested in vitro to verify wireless operation of the system in biological saline using a custom RF transmitter circuit and primary coils. Stimulation pulse strength, duration and frequency were programmed wirelessly using a custom graphical user interface. Operation of the retinal implant has been verified in vivo in one pig for more than three months by measuring stimulus artifacts on the eye surface using a contact lens electrode.en
dc.description.sponsorshipNational Science Foundation (IIS-0515134)en
dc.description.sponsorshipNational Institutes of Health (EY016674-01)en
dc.description.sponsorshipMOSIS Serviceen
dc.description.sponsorshipCatalyst Foundationen
dc.description.sponsorshipUnited States Dept. of Veteran Affairs. Center for Innovative Visual Rehabilitationen
dc.language.isoen_US
dc.publisherInstitute of Electrical and Electronics Engineersen
dc.relation.isversionofhttp://dx.doi.org/10.1109/IEMBS.2009.5333619en
dc.rightsArticle is made available in accordance with the publisher’s policy and may be subject to US copyright law. Please refer to the publisher’s site for terms of use.en
dc.sourceIEEEen
dc.titleRealization of a 15-channel, hermetically-encased wireless subretinal for the blinden
dc.typeArticleen
dc.identifier.citationKelly, S.K. et al. “Realization of a 15-channel, hermetically-encased wireless subretinal prosthesis for the blind.” Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE. 2009. 200-203. © 2009 IEEEen
dc.contributor.departmentMassachusetts Institute of Technology. Department of Electrical Engineering and Computer Scienceen_US
dc.contributor.departmentMassachusetts Institute of Technology. Research Laboratory of Electronicsen_US
dc.contributor.approverChen, Jinghua
dc.contributor.mitauthorWyatt, John L.
dc.contributor.mitauthorDrohan, William A.
dc.contributor.mitauthorDoyle, Patrick S.
dc.contributor.mitauthorKelly, Shawn K.
dc.relation.journal2009 Engineering in Medicine and Biology Societyen
dc.eprint.versionFinal published versionen
dc.type.urihttp://purl.org/eprint/type/ConferencePaperen
eprint.statushttp://purl.org/eprint/status/PeerRevieweden
dspace.orderedauthorsKelly, S.K.; Shire, D.B.; Jinghua Chen, D.B.; Doyle, P.; Gingerich, M.D.; Drohan, W.A.; Theogarajan, L.S.; Cogan, S.F.; Wyatt, J.L.; Rizzo, J.F.en
dc.identifier.orcidhttps://orcid.org/0000-0003-3533-5268
dc.identifier.orcidhttps://orcid.org/0000-0003-0044-4317
mit.licensePUBLISHER_POLICYen


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