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Cross Species Genomic Analysis Identifies a Mouse Model as Undifferentiated Pleomorphic Sarcoma/Malignant Fibrous Histiocytoma

dc.contributor.authorKirsch, David G.
dc.contributor.authorMukherjee, Sayan
dc.contributor.authorLev, Dina
dc.contributor.authorBrigman, Brian E.
dc.contributor.authorYoon, Sam S.
dc.contributor.authorHornicek, Francis J.
dc.contributor.authorEward, William C.
dc.contributor.authorStangenberg, Lars
dc.contributor.authorDodd, Rebecca D.
dc.contributor.authorLazar, Alexander J.
dc.contributor.authorLahat, Guy
dc.contributor.authorDodd, Leslie
dc.contributor.authorRiedel, Richard F.
dc.contributor.authorMito, Jeffrey K.
dc.contributor.authorJacks, Tyler E
dc.date.accessioned2010-05-05T20:15:48Z
dc.date.available2010-05-05T20:15:48Z
dc.date.issued2009-11
dc.date.submitted2009-10
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/1721.1/54724
dc.description.abstractUndifferentiated pleomorphic sarcoma/Malignant Fibrous Histiocytoma (MFH) is one of the most common subtypes of human soft tissue sarcoma. Using cross species genomic analysis, we define a geneset from the LSL-Kras[superscript G12D]; Trp53[superscript Flox/Flox] mouse model of soft tissue sarcoma that is highly enriched in human MFH. With this mouse geneset as a filter, we identify expression of the RAS target FOXM1 in human MFH. Expression of Foxm1 is elevated in mouse sarcomas that metastasize to the lung and tissue microarray analysis of human MFH correlates overexpression of FOXM1 with metastasis. These results suggest that genomic alterations present in human MFH are conserved in the LSL-Kras[superscript G12D]; p53[superscript Flox/Flox] mouse model of soft tissue sarcoma and demonstrate the utility of this pre-clinical model.en
dc.language.isoen_US
dc.publisherPublic Library of Scienceen
dc.relation.isversionofhttp://dx.doi.org/10.1371/journal.pone.0008075en
dc.rightsCreative Commons Attributionen
dc.rights.urihttp://creativecommons.org/licenses/by/2.5/en
dc.sourcePLoSen
dc.titleCross Species Genomic Analysis Identifies a Mouse Model as Undifferentiated Pleomorphic Sarcoma/Malignant Fibrous Histiocytomaen
dc.typeArticleen
dc.identifier.citationMito, Jeffrey K. et al. “Cross Species Genomic Analysis Identifies a Mouse Model as Undifferentiated Pleomorphic Sarcoma/Malignant Fibrous Histiocytoma.” PLoS ONE 4.11 (2009): e8075.en
dc.contributor.departmentKoch Institute for Integrative Cancer Research at MITen_US
dc.contributor.approverJacks, Tyler E.
dc.contributor.mitauthorJacks, Tyler E.
dc.relation.journalPLoS ONEen
dc.eprint.versionFinal published versionen
dc.type.urihttp://purl.org/eprint/type/JournalArticleen
eprint.statushttp://purl.org/eprint/status/PeerRevieweden
dspace.orderedauthorsMito, Jeffrey K.; Riedel, Richard F.; Dodd, Leslie; Lahat, Guy; Lazar, Alexander J.; Dodd, Rebecca D.; Stangenberg, Lars; Eward, William C.; Hornicek, Francis J.; Yoon, Sam S.; Brigman, Brian E.; Jacks, Tyler; Lev, Dina; Mukherjee, Sayan; Kirsch, David G.en
dc.identifier.orcidhttps://orcid.org/0000-0001-5785-8911
mit.licensePUBLISHER_CCen
mit.metadata.statusComplete


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