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Unraveling Infectious Structures, Strain Variants and Species Barriers for the Yeast Prion [PSI+]

Author(s)
Lindquist, Susan; Tessier, Peter M.
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Alternative title
Unraveling infectious structures, strain variants and species barriers for the yeast prion [PSI+]
Terms of use
Attribution-Noncommercial-Share Alike 3.0 Unported http://creativecommons.org/licenses/by-nc-sa/3.0/
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Abstract
Prions are proteins that can access multiple conformations, at least one of which is beta-sheet rich, infectious and self-perpetuating in nature. These infectious proteins show several remarkable biological activities, including the ability to form multiple infectious prion conformations, also known as strains or variants, encoding unique biological phenotypes, and to establish and overcome prion species (transmission) barriers. In this Perspective, we highlight recent studies of the yeast prion [PSI+], using various biochemical and structural methods, that have begun to illuminate the molecular mechanisms by which self-perpetuating prions encipher such biological activities. We also discuss several aspects of prion conformational change and structure that remain either unknown or controversial, and we propose approaches to accelerate the understanding of these enigmatic, infectious conformers.
Date issued
2009-06
URI
http://hdl.handle.net/1721.1/54769
Department
Massachusetts Institute of Technology. Department of Biology
Journal
Nature Structural & Molecular Biology
Publisher
Nature Publishing Group
Citation
Tessier, Peter M, and Susan Lindquist. “Unraveling infectious structures, strain variants and species barriers for the yeast prion [PSI+].” Nat Struct Mol Biol 16.6 (2009): 598-605.
Version: Author's final manuscript
ISSN
1545-9985
1545-9993

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