dc.contributor.author | Asada, Harry | |
dc.contributor.author | Das, Anusuya | |
dc.contributor.author | Wood, Levi Benjamin | |
dc.contributor.author | Kamm, Roger Dale | |
dc.date.accessioned | 2010-05-12T20:10:00Z | |
dc.date.available | 2010-05-12T20:10:00Z | |
dc.date.issued | 2009-07 | |
dc.date.submitted | 2009-05 | |
dc.identifier.issn | 0018-9294 | |
dc.identifier.other | PubMed ID: 19622435 | |
dc.identifier.other | INSPEC Accession Number: 10828631 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/54776 | |
dc.description.abstract | This paper presents a framework for controlling the
development of a vascular system in an in vitro angiogenesis process.
Based on online measurement of cell growth and a stochastic
cell population model, a closed-loop control system is developed
for regulating the process of cell migration and vascular system
development. Angiogenesis is considered in a microfluidic environment,
where chemical and mechanical stimuli can be applied to
the cell population. A systems-level description of the angiogenesis
process is formulated, and a control scheme that chooses an
optimal sequence of control inputs to drive collective cell patterns
toward a desired goal is presented in this paper. In response to
control inputs, the k-step ahead prediction of morphologic pattern
measures is evaluated, and the input that minimizes expected
squared error between the future measure and its desired value
is selected for the current control. Initial simulation experiments
demonstrate that vascular development can be guided toward a
desired morphologic pattern using this technique. | en |
dc.description.sponsorship | National Science Foundation (Grant NSFEFRI- 0735997) | en |
dc.language.iso | en_US | |
dc.publisher | Institute of Electrical and Electronics Engineers | en |
dc.relation.isversionof | http://dx.doi.org/10.1109/TBME.2009.2026732 | en |
dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en |
dc.source | IEEE | en |
dc.subject | vascular development | en |
dc.subject | stochastic processes | en |
dc.subject | population $hbox{control}$ | en |
dc.subject | microfluidic devices | en |
dc.subject | biological systems | en |
dc.subject | biological cells | en |
dc.subject | biological $hbox{control}$ systems | en |
dc.subject | Angiogenesis | en |
dc.title | A stochastic broadcast feedback approach to regulating cell population for microfluidic angiogenesis platforms | en |
dc.type | Article | en |
dc.identifier.citation | Wood, L.B. et al. “A Stochastic Broadcast Feedback Approach to Regulating Cell Population Morphology for Microfluidic Angiogenesis Platforms.” Biomedical Engineering, IEEE Transactions on 56.9 (2009): 2299-2303. © 2009 Institute of Electrical and Electronics Engineers. | en |
dc.contributor.department | Massachusetts Institute of Technology. Department of Biological Engineering | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Mechanical Engineering | en_US |
dc.contributor.approver | Kamm, Roger Dale | |
dc.contributor.mitauthor | Asada, Harry | |
dc.contributor.mitauthor | Das, Anusuya | |
dc.contributor.mitauthor | Wood, Levi Benjamin | |
dc.contributor.mitauthor | Kamm, Roger Dale | |
dc.relation.journal | IEEE Transactions on Biomedical Engineering | en |
dc.eprint.version | Final published version | en |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en |
dspace.orderedauthors | Wood, L.B.; Das, A.; Kamm, R.D.; Asada, H.H. | en |
dc.identifier.orcid | https://orcid.org/0000-0003-3155-6223 | |
dc.identifier.orcid | https://orcid.org/0000-0002-7232-304X | |
mit.license | PUBLISHER_POLICY | en |
mit.metadata.status | Complete | |