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dc.contributor.authorAsada, Harry
dc.contributor.authorDas, Anusuya
dc.contributor.authorWood, Levi Benjamin
dc.contributor.authorKamm, Roger Dale
dc.date.accessioned2010-05-12T20:10:00Z
dc.date.available2010-05-12T20:10:00Z
dc.date.issued2009-07
dc.date.submitted2009-05
dc.identifier.issn0018-9294
dc.identifier.otherPubMed ID: 19622435
dc.identifier.otherINSPEC Accession Number: 10828631
dc.identifier.urihttp://hdl.handle.net/1721.1/54776
dc.description.abstractThis paper presents a framework for controlling the development of a vascular system in an in vitro angiogenesis process. Based on online measurement of cell growth and a stochastic cell population model, a closed-loop control system is developed for regulating the process of cell migration and vascular system development. Angiogenesis is considered in a microfluidic environment, where chemical and mechanical stimuli can be applied to the cell population. A systems-level description of the angiogenesis process is formulated, and a control scheme that chooses an optimal sequence of control inputs to drive collective cell patterns toward a desired goal is presented in this paper. In response to control inputs, the k-step ahead prediction of morphologic pattern measures is evaluated, and the input that minimizes expected squared error between the future measure and its desired value is selected for the current control. Initial simulation experiments demonstrate that vascular development can be guided toward a desired morphologic pattern using this technique.en
dc.description.sponsorshipNational Science Foundation (Grant NSFEFRI- 0735997)en
dc.language.isoen_US
dc.publisherInstitute of Electrical and Electronics Engineersen
dc.relation.isversionofhttp://dx.doi.org/10.1109/TBME.2009.2026732en
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en
dc.sourceIEEEen
dc.subjectvascular developmenten
dc.subjectstochastic processesen
dc.subjectpopulation $hbox{control}$en
dc.subjectmicrofluidic devicesen
dc.subjectbiological systemsen
dc.subjectbiological cellsen
dc.subjectbiological $hbox{control}$ systemsen
dc.subjectAngiogenesisen
dc.titleA stochastic broadcast feedback approach to regulating cell population for microfluidic angiogenesis platformsen
dc.typeArticleen
dc.identifier.citationWood, L.B. et al. “A Stochastic Broadcast Feedback Approach to Regulating Cell Population Morphology for Microfluidic Angiogenesis Platforms.” Biomedical Engineering, IEEE Transactions on 56.9 (2009): 2299-2303. © 2009 Institute of Electrical and Electronics Engineers.en
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Mechanical Engineeringen_US
dc.contributor.approverKamm, Roger Dale
dc.contributor.mitauthorAsada, Harry
dc.contributor.mitauthorDas, Anusuya
dc.contributor.mitauthorWood, Levi Benjamin
dc.contributor.mitauthorKamm, Roger Dale
dc.relation.journalIEEE Transactions on Biomedical Engineeringen
dc.eprint.versionFinal published versionen
dc.type.urihttp://purl.org/eprint/type/JournalArticleen
eprint.statushttp://purl.org/eprint/status/PeerRevieweden
dspace.orderedauthorsWood, L.B.; Das, A.; Kamm, R.D.; Asada, H.H.en
dc.identifier.orcidhttps://orcid.org/0000-0003-3155-6223
dc.identifier.orcidhttps://orcid.org/0000-0002-7232-304X
mit.licensePUBLISHER_POLICYen
mit.metadata.statusComplete


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