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Ipsilateral cortical fMRI responses after peripheral nerve damage in rats reflect increased interneuron activity

Author(s)
Tierney, Patrick L.; Koretsky, Alan P.; Walters, Judith R.; Leopold, David A.; Yu, David; Chuang, Kai-Hsiang; Conroy, Richard S.; Bergstrom, Debra A.; Pelled, Galit; ... Show more Show less
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Abstract
In the weeks following unilateral peripheral nerve injury, the deprived primary somatosensory cortex (SI) responds to stimulation of the ipsilateral intact limb as demonstrated by functional magnetic resonance imaging (fMRI) responses. The neuronal basis of these responses was studied by using high-resolution fMRI, in vivo electrophysiological recordings, and juxtacellular neuronal labeling in rats that underwent an excision of the forepaw radial, median, and ulnar nerves. These nerves were exposed but not severed in control rats. Significant bilateral increases of fMRI responses in SI were observed in denervated rats. In the healthy SI of the denervated rats, increases in fMRI responses were concordant with increases in local field potential (LFP) amplitude and an increased incidence of single units responding compared with control rats. In contrast, in the deprived SI, increases in fMRI responses were associated with a minimal change in LFP amplitude but with increased incidence of single units responding. Based on action potential duration, juxtacellular labeling, and immunostaining results, neurons responding to intact forepaw stimulation in the deprived cortex were identified as interneurons. These results suggest that the increases in fMRI responses in the deprived cortex reflect increased interneuron activity.
Date issued
2009-08
URI
http://hdl.handle.net/1721.1/55303
Department
McGovern Institute for Brain Research at MIT
Journal
Proceedings of the National Academy of Sciences of the United States of America
Publisher
United States National Academy of Sciences
Citation
Pelled, Galit et al. “Ipsilateral cortical fMRI responses after peripheral nerve damage in rats reflect increased interneuron activity.” Proceedings of the National Academy of Sciences 106.33 (2009): 14114-14119. © 2009 National Academy of Sciences
Version: Final published version
ISSN
1091-6490
0027-8424

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