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dc.contributor.authorOlsen, Rosanna K.
dc.contributor.authorNichols, Elizabeth A.
dc.contributor.authorChen, Janice
dc.contributor.authorHunt, Jack F.
dc.contributor.authorGlover, Gary H.
dc.contributor.authorWagner, Anthony D.
dc.contributor.authorGabrieli, John D. E.
dc.date.accessioned2010-06-25T15:13:59Z
dc.date.available2010-06-25T15:13:59Z
dc.date.issued2009-09
dc.date.submitted2009-08
dc.identifier.issn1529-2401
dc.identifier.urihttp://hdl.handle.net/1721.1/55964
dc.description.abstractThe medial temporal lobe (MTL)—hippocampus and surrounding perirhinal, parahippocampal, and entorhinal cortical areas—has long been known to be critical for long-term memory for events. Recent functional neuroimaging and neuropsychological data in humans performing short-delay tasks suggest that the MTL also contributes to performance even when retention intervals are brief, and single-unit data in rodents reveal sustained, performance-related delay activity in the MTL during delayed-non-match-to-sample tasks. The current study used functional magnetic resonance imaging to examine the relationship between activation in human MTL subregions and performance during a delayed-match-to-sample task with repeated (non-trial-unique) stimuli. On critical trials, the presentation of two faces was followed by a 30 s delay period, after which participants performed two-alternative forced-choice recognition. Functional magnetic resonance imaging revealed significant delay period activity in anterior hippocampus, entorhinal cortex, and perirhinal cortex over the 30 s retention interval, with the magnitude of activity being significantly higher on subsequently correct compared with subsequently incorrect trials. In contrast, posterior hippocampus, parahippocampal cortex, and fusiform gyrus activity linearly increased across the 30 s delay, suggesting an anticipatory response, and activity in parahippocampal cortex and hippocampus was greater during the probe period on correct compared with incorrect trials. These results indicate that at least two patterns of MTL delay period activation—sustained and anticipatory—are present during performance of short-delay recognition memory tasks, providing novel evidence that multiple processes govern task performance. Implications for understanding the role of the hippocampus and surrounding MTL cortical areas in recognition memory after short delays are discussed.en_US
dc.description.sponsorshipNational Institute of Mental Health (Grant 5R01-MH076932)en_US
dc.description.sponsorshipNational Science Foundationen_US
dc.description.sponsorshipNational Alliance for Research on Schizophrenia and Depressionen_US
dc.description.sponsorshipAlfred P. Sloan Foundationen_US
dc.language.isoen_US
dc.publisherSociety for Neuroscienceen_US
dc.relation.isversionofhttp://dx.doi.org/10.1523/jneurosci.2245-09.2009en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourceSociety for Neuroscienceen_US
dc.titlePerformance-Related Sustained and Anticipatory Activity in Human Medial Temporal Lobe during Delayed Match-to-Sampleen_US
dc.typeArticleen_US
dc.identifier.citationOlsen, Rosanna K et al. “Performance-Related Sustained and Anticipatory Activity in Human Medial Temporal Lobe during Delayed Match-to-Sample.” J. Neurosci. 29.38 (2009): 11880-11890. © 2009 The Society for Neuroscienceen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Brain and Cognitive Sciencesen_US
dc.contributor.approverGabrieli, John D. E.
dc.contributor.mitauthorGabrieli, John D. E.
dc.relation.journalJournal of Neuroscienceen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsOlsen, R. K.; Nichols, E. A.; Chen, J.; Hunt, J. F.; Glover, G. H.; Gabrieli, J. D. E.; Wagner, A. D.en
dc.identifier.orcidhttps://orcid.org/0000-0003-1158-5692
mit.licensePUBLISHER_POLICYen_US
mit.metadata.statusComplete


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